Bristol Biobank

Fit and well (finding)

D0001 Swine Flu (Novel Influenza A H1N1) Vaccine Study

Year Started: 2009

Two new vaccines (Baxter swine flu & GSK swine flu vaccine) have been made against swine flu in response to the pandemic. These vaccines have been tested in adults, but there is less information on how well they work in children. This study will assess these two new vaccines in children aged between six months and twelve years



Access:
Access restricted at present
Type:
Clinical Trial
Status:
Completed
Consent restrictions:
No restrictions


Associated Data Type Procurement Timeframe
There is no associated data for this collection.


Male

Infant (1 month - 2 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
DNA -60°C to -85°C N/A Not applicable 0 - 10%
Serum -60°C to -85°C N/A Not applicable 11 - 25%
Whole blood -60°C to -85°C N/A Not applicable 0 - 10%


Female

Infant (1 month - 2 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
DNA -60°C to -85°C N/A Not applicable 0 - 10%
Serum -60°C to -85°C N/A Not applicable 0 - 10%
Whole blood -60°C to -85°C N/A Not applicable 0 - 10%

Tonsillitis (disorder)

D0004 Deposit of tonsils, adenoids and additional samples

Year Started: 2009

Children going for adenotonsillectomy, tonsillectomy or adenoidectomy will be approached to donate samples. Additional samples to be collected at this time may include saliva samples, urine samples, a blood sample and a nasal swab



Access:
Access restricted at present
Type:
Clinical Trial
Status:
Completed
Consent restrictions:
No restrictions


Associated Data Type Procurement Timeframe
There is no associated data for this collection.


Female

Infant (1 month - 2 years)

1 - 10 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Tissue specimen Surgical procedure (procedure) -60°C to -85°C N/A Not applicable 0 - 10%


Male

Infant (1 month - 2 years)

1 - 10 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Tissue specimen Surgical procedure (procedure) -60°C to -85°C N/A Not applicable 0 - 10%

Fit and well (finding)

D0008 Multi-centre Study to Evaluate the Safety, Tolerability and Immunogenicity of Baxter H1N1 vaccine and GlaxoSmithKline H1N1 vaccine in children 6 months to 12 years of age

Year Started: 2009

D0008 Multi-centre Study to Evaluate the Safety, Tolerability and Immunogenicity of Baxter H1N1 vaccine and GlaxoSmithKline H1N1 vaccine in children 6 months to 12 years of age



Access:
Access restricted at present
Type:
Clinical Trial
Status:
Completed
Consent restrictions:
No restrictions


Associated Data Type Procurement Timeframe
There is no associated data for this collection.


Female

Infant (1 month - 2 years)

1 - 10 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Serum -60°C to -85°C N/A Not applicable 0 - 10%


Male

Infant (1 month - 2 years)

1 - 10 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Serum -60°C to -85°C N/A Not applicable 0 - 10%

Fit and well (finding)

D0009 Study to evaluate the induction of immune memory following infant vaccination with a glycol-conjugate Neisseria Meningitidis serogroup C Vaccine

Year Started: 2011

Please note, this collection consists of blood clots but it is listed as plasma. Study to evaluate the induction of immune memory following infant vaccination with a glycol-conjugate Neisseria Meningitidis serogroup C Vaccine and to assess the immune response to the concurrent infant routine immunisations administered in consistent versus alternating limbs.



Access:
Access restricted at present
Type:
Clinical Trial
Status:
Completed
Consent restrictions:
No restrictions


Associated Data Type Procurement Timeframe
There is no associated data for this collection.


Female

Infant (1 month - 2 years)

1 - 10 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Serum -60°C to -85°C N/A Not applicable 0 - 10%


Male

Infant (1 month - 2 years)

1 - 10 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Serum -60°C to -85°C N/A Not applicable 0 - 10%

Fit and well (finding)

D0015 Improved diagnosis of meningococcal, pneumococcal and group A streptococcal infections

Year Started: 2005

Improved diagnosis of meningococcal, pneumococcal and group A streptococcal infections



Access:
Access restricted at present
Type:
Disease specific
Status:
Completed
Consent restrictions:
No restrictions


Associated Data Type Procurement Timeframe
There is no associated data for this collection.


Female

Infant (1 month - 2 years)

1 - 10 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Serum -60°C to -85°C N/A Not applicable 0 - 10%


Female

Infant (1 month - 2 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Saliva -60°C to -85°C N/A Not applicable 0 - 10%


Male

Infant (1 month - 2 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Saliva -60°C to -85°C N/A Not applicable 0 - 10%


Female

Infant (1 month - 2 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Urine -60°C to -85°C N/A Not applicable 0 - 10%


Female

Infant (1 month - 2 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Urine -60°C to -85°C N/A Not applicable 0 - 10%


Male

Infant (1 month - 2 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Urine -60°C to -85°C N/A Not applicable 0 - 10%


Female

Infant (1 month - 2 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Whole blood -60°C to -85°C N/A Not applicable 0 - 10%


Male

Infant (1 month - 2 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Whole blood -60°C to -85°C N/A Not applicable 0 - 10%


Female

Infant (1 month - 2 years)

1 - 10 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Swab -60°C to -85°C N/A Not applicable 0 - 10%


Male

Infant (1 month - 2 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Swab -60°C to -85°C N/A Not applicable 0 - 10%

Fit and well (finding)

D0016 Server, unusual, or recurrent community acquired infection in children- susceptibility, detection and immune response (CAI)

Year Started: 2006

What makes the bug choose your child, how can we find it and how can we stop it? The study is trying to improve our understanding of why some children get sick when others don’t, even though they must have been exposed to the same bugs. We are also trying to develop ways of finding out what has caused an infection, using ways which don’t rely on finding the bug itself (one example of this would be to test urine for evidence of the bug for example). The other part of the study is to use the information we can get from children who are infected by these bugs to help develop vaccines to increase our ability to prevent infections in the first place.



Access:
Access restricted at present
Type:
Disease specific
Status:
Completed
Consent restrictions:
No restrictions


Associated Data Type Procurement Timeframe
There is no associated data for this collection.


Male

Infant (1 month - 2 years)

1 - 10 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Swab -60°C to -85°C N/A Not applicable 0 - 10%


Female

Infant (1 month - 2 years)

1 - 10 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Urine -60°C to -85°C N/A Not applicable 0 - 10%


Male

Infant (1 month - 2 years)

1 - 10 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Urine -60°C to -85°C N/A Not applicable 0 - 10%


Female

Infant (1 month - 2 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Whole blood -60°C to -85°C N/A Not applicable 0 - 10%


Male

Infant (1 month - 2 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Whole blood -60°C to -85°C N/A Not applicable 0 - 10%


Female

Infant (1 month - 2 years)

1 - 10 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Saliva -60°C to -85°C N/A Not applicable 0 - 10%


Male

Infant (1 month - 2 years)

1 - 10 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Saliva -60°C to -85°C N/A Not applicable 0 - 10%


Female

Infant (1 month - 2 years)

1 - 10 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Swab -60°C to -85°C N/A Not applicable 0 - 10%

Fit and well (finding)

D0023 Study to demonstrate the efficacy of GlaxoSmithKline Biologicals’ quadrivalent seasonal influenza candidate vaccine GSK2321138A (FLU D-QIV), administered intramuscularly in children 9 to 35 months of age

Year Started: 2011

Please note, this collection consists of blood clots but it is listed as plasma. Study to demonstrate the efficacy of GlaxoSmithKline Biologicals’ quadrivalent seasonal influenza candidate vaccine GSK2321138A (FLU D-QIV), administered intramuscularly in children 9 to 35 months of age.



Access:
Access restricted at present
Type:
Clinical Trial
Status:
Completed
Consent restrictions:
No restrictions


Associated Data Type Procurement Timeframe
There is no associated data for this collection.


Female

Infant (1 month - 2 years)

1 - 10 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Plasma -60°C to -85°C N/A Not applicable 0 - 10%

Fit and well (finding)

D0026 Study to evaluate V419 (PR5I) given at 2, 3 & 4 months with two types of meningococcal serogroup C conjugate (MCC) vaccines given at 3 & 4 months, followed by a combined Haemophilus influenza type b-MCC vaccine at 12 months

Year Started: 2012

Please note, this collection consists of blood clots but it is listed as plasma. A phase III open-label randomised study, to evaluate the immunogenicity and safety of the concomitant administration of V419 (PR5I) given at 2, 3 and 4 months of age with two types of meningococcal serogroup C conjugate (MCC) vaccines given at 3 an 4 months of age, and followed by the administration at 12 months of age of a combined Haemophilus influenza type b-MCC vaccine.



Access:
Access restricted at present
Type:
Clinical Trial
Status:
Completed
Consent restrictions:
No restrictions


Associated Data Type Procurement Timeframe
There is no associated data for this collection.


Male

Infant (1 month - 2 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Plasma -60°C to -85°C N/A Not applicable 51 - 75%


Female

Infant (1 month - 2 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Plasma -60°C to -85°C N/A Not applicable 26 - 50%

Chronic multifocal osteomyelitis (disorder)

D0031 Duration of INtravenous antibiOtic therapy for Septic Arthritis or acUte osteomyelitis in a paediatRic population ("Dinosaur" end of study deposit)

Year Started: 2013

These blood samples are from children (1 year old – 16 years old) who were admitted for treatment for suspected or confirmed septic arthritis or osteomyelitis, and enrolled in the Dinosaur study.



Access:
Access restricted at present
Type:
Disease specific
Status:
Completed
Consent restrictions:
No restrictions


Associated Data Type Procurement Timeframe
There is no associated data for this collection.


Female

Infant (1 month - 2 years)

1 - 10 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Whole blood -60°C to -85°C N/A Not applicable 11 - 25%

Fit and well (finding)

D0032 The Bristol Nasal Colonisation Surveillance Study

Year Started: 2011

The effects of viral upper respiratory tract infections on bacterial colonisation of the nasopharynx in young healthy children attending day care centres. A single centre prospective longitudinal follow up study.



Access:
Access restricted at present
Type:
Clinical Trial
Status:
Completed
Consent restrictions:
No restrictions


Associated Data Type Procurement Timeframe
There is no associated data for this collection.


Female

Infant (1 month - 2 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Swab -60°C to -85°C N/A Not applicable 0 - 10%


Male

Infant (1 month - 2 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Swab -60°C to -85°C N/A Not applicable 0 - 10%


Male

Infant (1 month - 2 years)

1 - 10 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
RNA -60°C to -85°C N/A Not applicable 0 - 10%