Children going for adenotonsillectomy, tonsillectomy or adenoidectomy will be approached to donate samples. Additional samples to be collected at this time may include saliva samples, urine samples, a blood sample and a nasal swab

Please note, this collection consists of blood clots but it is listed as plasma. Study to evaluate the induction of immune memory following infant vaccination with a glycol-conjugate Neisseria Meningitidis serogroup C Vaccine and to assess the immune response to the concurrent infant routine immunisations administered in consistent versus alternating limbs.

A multi-centre, open-label, clinical, phase 4 trial, following on from a head-to-head comparison study of two H1N1 influenza vaccines in children, to compare firstly, the persistence of antibody against the A/California/7/2009 (H1N1) virus and secondly the immunogenicity and reactogenicity of one dose of a non-adjuvanted trivalent seasonal influenza vaccine, in children who had received a two-dose immunisation regimen of Celvapan or Pandemrix.

A multi-centre, open-label, clinical, phase 4 trial, following on from a head-to-head comparison study of two H1N1 influenza vaccines in children, to compare firstly, the persistence of antibody against the A/California/7/2009 (H1N1) virus and secondly the immunogenicity and reactogenicity of one dose of a non-adjuvanted trivalent seasonal influenza vaccine, in children who had received a two-dose immunisation regimen of Celvapan or Pandemrix.

Improved diagnosis of meningococcal, pneumococcal and group A streptococcal infections

What makes the bug choose your child, how can we find it and how can we stop it? The study is trying to improve our understanding of why some children get sick when others don’t, even though they must have been exposed to the same bugs. We are also trying to develop ways of finding out what has caused an infection, using ways which don’t rely on finding the bug itself (one example of this would be to test urine for evidence of the bug for example). The other part of the study is to use the information we can get from children who are infected by these bugs to help develop vaccines to increase our ability to prevent infections in the first place.

These blood samples are from children (1 year old – 16 years old) who were admitted for treatment for suspected or confirmed septic arthritis or osteomyelitis, and enrolled in the Dinosaur study.

Samples were collected as part of the “PATH longitudinal study” from a total of 60 healthy children aged 0-16 years when they were undergoing routine adenoidectomy or adenotonsillectomy surgery.