Malignant tumor of pancreas (disorder)
Clinical Trial: SPARC
Year Started: 2015
A phase 1 trial of pre-operative, margin intensive, stereotactic body radiation therapy for pancreatic cancer
- Access:
- Access restricted at present
- Type:
- Clinical Trial
- Status:
- In progress
- Consent restrictions:
- No restrictions
Associated Data Type | Procurement Timeframe |
---|---|
Followup records | 0 - 3 months |
Imaging data | 0 - 3 months |
Pathology records | 0 - 3 months |
Physiological/biochemical measurements | 0 - 3 months |
Treatment records | 0 - 3 months |
Male
Adult (> 40 years)
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | N/A | Not applicable | 0 - 10% |
Female
Adult (> 40 years)
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | N/A | Not applicable | 0 - 10% |
Male
Adult (> 40 years)
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Peripheral blood mononuclear cells (PBMC) | -60°C to -85°C | N/A | Not applicable | 0 - 10% |
Female
Adult (> 40 years)
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Peripheral blood mononuclear cells (PBMC) | -60°C to -85°C | N/A | Not applicable | 0 - 10% |
Male
Adult (> 40 years)
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Plasma | -60°C to -85°C | N/A | Not applicable | 0 - 10% |
Female
Adult (> 40 years)
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Plasma | -60°C to -85°C | N/A | Not applicable | 0 - 10% |
Local recurrence of malignant tumor of pancreas (disorder)
Clinical Trial: SCALOP-2
Year Started: 2017
T-SCALOP is the translational sample collection associated with the SCALOP-2 trial. The SCALOP2 trial is a randomised phase II/III study with a 2x2 factorial design plus an additional chemotherapy control arm in patients with locally advanced non-metastatic pancreatic cancer. Patients whose disease remains stable after treatment with gemcitabine and abraxane will be randomised to one of five arms, consisting of capecitabine in combination with radiotherapy, with and without inclusion of the Phospho-AKT inhibitor nelfinavir, and a chemotherapy control arm receiving gemcitabine and abraxane alone. The study aims to recruit 262 patients over a period of 48 months from 40 UK centres. T-SCALOP aims to establish a collection of samples focusing on developing blood-borne biomarkers for tumour detection and response prediction. In addition to residual tumour tissue from diagnostic biopsy, research blood will be collected from patients at trial entry, start of chemoradiotherapy, 4-6 weeks after chemoradiotherapy and at progression. The samples will be used to compare tumour DNA with circulating cell-free plasma DNA to determine whether blood borne biomarkers can be used as a surrogate for primary tumour. They will also help determine whether alteration in the levels of specific somatic events correlate with benefit of a given intervention. The collection will also help to evaluate plasma biomarkers related to hypoxia before and during nelfinivir treatment and correlate with clinical outcome. The sample collection has been held in the Wales Cancer Bank since 2022. For sample enquiries, please contact WCB directly.
- Access:
- Access restricted at present
- Type:
- Clinical Trial
- Status:
- Completed
- Consent restrictions:
- No restrictions
Associated Data Type | Procurement Timeframe |
---|---|
Clinical records | > 6 months |
Followup records | > 6 months |
Pathology records | > 6 months |
Female
Adult (> 40 years)
101 - 500 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Plasma | -60°C to -85°C | N/A | Not applicable | 51 - 75% |
Male
Adult (> 40 years)
101 - 500 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Plasma | -60°C to -85°C | N/A | Not applicable | 51 - 75% |
Male
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Serum | -60°C to -85°C | N/A | Not applicable | 0 - 10% |
Female
Adult (> 40 years)
101 - 500 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Serum | -60°C to -85°C | N/A | Not applicable | 51 - 75% |
Male
Adult (> 40 years)
101 - 500 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Tissue specimen | Surgical procedure (procedure) | RT | Paraffin | Not applicable | 51 - 75% |
Female
Adult (> 40 years)
101 - 500 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Tissue specimen | Surgical procedure (procedure) | RT | Paraffin | Not applicable | 51 - 75% |
Malignant tumor of lung (disorder)
Clinical Trial: ARCADIAN
Year Started: 2021
A phase I dose escalation study to investigate combining the antimalarial drug atovaquone with chemoradiotherapy in non-small cell lung cancer, using a time to event continual reassessment method (TiTE CRM).
- Access:
- Access restricted at present
- Type:
- Clinical Trial
- Status:
- In progress
- Consent restrictions:
- No restrictions
Associated Data Type | Procurement Timeframe |
---|---|
Biomarker datasets | > 6 months |
Followup records | > 6 months |
Imaging data | > 6 months |
Physiological/biochemical measurements | > 6 months |
Treatment records | > 6 months |
Female
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Plasma | -60°C to -85°C | Not applicable | 75% -99% |
Male
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Plasma | -60°C to -85°C | Not applicable | 75% -99% |
Female
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Tissue specimen | RT | Paraffin | Not applicable | 75% -99% |
Male
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Tissue specimen | RT | Paraffin | Not applicable | 75% -99% |