Diabetes mellitus type 1 (disorder)

Exeter Archival Diabetes Biobank (EADB)

Year Started: 1980

During his career as a pathologist working in Scotland, Professor Alan Foulis compiled the world’s largest collection of autopsy pancreas samples recovered from patients who died shortly after receiving a diagnosis of type 1 diabetes. This collection was first assembled in the early 1980s from centres across the UK and it consists of nearly 170 cases in total, more than 100 of which are from young people (<20 years old) with recent-onset type 1 diabetes. The samples were originally held in Glasgow but, upon his retirement in 2015, Professor Foulis transferred them to University of Exeter Medical School, where they are now retained. Study of these cases has been hugely influential in shaping our current understanding of the aetiology of type 1 diabetes. Although it is now more than 30 years since this collection was first compiled by Alan Foulis, it continues to represent an invaluable resource for research into the causes of type 1 diabetes and is likely to do so for many years to come.



Access:
Open only through collaboration
Type:
Disease specific
Status:
Completed
Consent restrictions:
No restrictions


Associated Data Type Procurement Timeframe
There is no associated data for this collection.


Male

Young adult (18 - 40 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
PM tissue RT N/A Affected 100%


Female

Young adult (18 - 40 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
PM tissue RT N/A Affected 100%

Diabetes mellitus type 1 (disorder)

Diabetes Alliance for Research in England (DARE)

Year Started: 2009

The DARE study consists of samples from diabetic patients, both type 1 and type 2 in the South West peninsula area (roughly Devon and Cornwall), predominately within the Exeter area. Sample collected at point of contact and data collected over time. The DARE collection was run alongside our EXTEND collection, concentrating on diabetic patients. EXTEND patients were recruited as controls to the DARE collection, and DARE diabetics were recruited to the EXTEND collection. Therefore, the majority of patients in DARE will have samples held within EXTEND, however, if diabetes is the main focus of a request to the Exeter biobanks, samples and data will come from the DARE collection. Please see http://www.diabetesgenes.org/content/diabetes-alliance-research-england-dare-previously-known-exeter-research-alliance-extra-stud for more information



Access:
Open only through collaboration
Type:
Disease specific
Status:
Completed
Consent restrictions:
Other animal work restriction, Xenograft restriction


Associated Data Type Procurement Timeframe
Biomarker datasets 0 - 3 months
Clinical records 0 - 3 months
Cold ischemic time 0 - 3 months
Followup records 0 - 3 months
Freezer temperature logs 0 - 3 months
Genomic datasets 0 - 3 months
Physiological/biochemical measurements 0 - 3 months
Primary care records 0 - 3 months
Quality indicators 0 - 3 months


Male

Young adult (18 - 40 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
DNA -60°C to -85°C N/A Not applicable 75% -99%
Plasma -60°C to -85°C N/A Not applicable 26 - 50%
Serum -60°C to -85°C N/A Not applicable 26 - 50%
Urine -60°C to -85°C N/A Not applicable 26 - 50%


Female

Young adult (18 - 40 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
DNA -60°C to -85°C N/A Not applicable 75% -99%
Plasma -60°C to -85°C N/A Not applicable 26 - 50%
Serum -60°C to -85°C N/A Not applicable 26 - 50%
Urine -60°C to -85°C N/A Not applicable 26 - 50%

Diabetes mellitus type 2 (disorder)

Diabetes Alliance for Research in England (DARE)

Year Started: 2009

The DARE study consists of samples from diabetic patients, both type 1 and type 2 in the South West peninsula area (roughly Devon and Cornwall), predominately within the Exeter area. Sample collected at point of contact and data collected over time. The DARE collection was run alongside our EXTEND collection, concentrating on diabetic patients. EXTEND patients were recruited as controls to the DARE collection, and DARE diabetics were recruited to the EXTEND collection. Therefore, the majority of patients in DARE will have samples held within EXTEND, however, if diabetes is the main focus of a request to the Exeter biobanks, samples and data will come from the DARE collection. Please see http://www.diabetesgenes.org/content/diabetes-alliance-research-england-dare-previously-known-exeter-research-alliance-extra-stud for more information



Access:
Open only through collaboration
Type:
Disease specific
Status:
Completed
Consent restrictions:
Other animal work restriction, Xenograft restriction


Associated Data Type Procurement Timeframe
Biomarker datasets 0 - 3 months
Clinical records 0 - 3 months
Cold ischemic time 0 - 3 months
Followup records 0 - 3 months
Freezer temperature logs 0 - 3 months
Genomic datasets 0 - 3 months
Physiological/biochemical measurements 0 - 3 months
Primary care records 0 - 3 months
Quality indicators 0 - 3 months


Male

Young adult (18 - 40 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
DNA -60°C to -85°C N/A Not applicable 75% -99%
Plasma -60°C to -85°C N/A Not applicable 26 - 50%
Serum -60°C to -85°C N/A Not applicable 26 - 50%
Urine -60°C to -85°C N/A Not applicable 26 - 50%


Female

Young adult (18 - 40 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
DNA -60°C to -85°C N/A Not applicable 75% -99%
Plasma -60°C to -85°C N/A Not applicable 26 - 50%
Serum -60°C to -85°C N/A Not applicable 26 - 50%
Urine -60°C to -85°C N/A Not applicable 26 - 50%