Diabetes mellitus type 1 (disorder)
Exeter Archival Diabetes Biobank (EADB)
Year Started: 1980
During his career as a pathologist working in Scotland, Professor Alan Foulis compiled the world’s largest collection of autopsy pancreas samples recovered from patients who died shortly after receiving a diagnosis of type 1 diabetes. This collection was first assembled in the early 1980s from centres across the UK and it consists of nearly 170 cases in total, more than 100 of which are from young people (<20 years old) with recent-onset type 1 diabetes. The samples were originally held in Glasgow but, upon his retirement in 2015, Professor Foulis transferred them to University of Exeter Medical School, where they are now retained. Study of these cases has been hugely influential in shaping our current understanding of the aetiology of type 1 diabetes. Although it is now more than 30 years since this collection was first compiled by Alan Foulis, it continues to represent an invaluable resource for research into the causes of type 1 diabetes and is likely to do so for many years to come.
- Access:
- Open only through collaboration
- Type:
- Disease specific
- Status:
- Completed
- Consent restrictions:
- No restrictions
Associated Data Type | Procurement Timeframe |
---|---|
There is no associated data for this collection. |
Female
Young child (2 - 6 years)
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
PM tissue | RT | N/A | Affected | 100% |
Diabetes mellitus type 1 (disorder)
UNITED - Using Pharmacogenetics to Improve Treatment in Early-onset Diabetes
Year Started: 2010
The UNITED study was a population-based study looking at individuals aged below 50 years, diagnosed with diabetes before the age of 30 years. Typically, such individuals will be diagnosed with Type 1 (T1DM) but a number of these individuals will in fact have a form of monogenic diabetes. Often, these subsets of diabetes respond better to treatments other than insulin, or no treatment at all. UNITED participants underwent a 3 step algorithm with progression to the next step being determined by their results. All participants had an initial UCPCR test, unless their diabetes treatment was diet only (and therefore producing insulin), to measure endogenous insulin. Participants that were UCPCR positive and producing insulin were tested for pancreatic autoantibodies to determine the likelihood of having type 1 diabetes. The final stage of the UNITED pathway was for those with negative autoantibodies and endogenous insulin production to undergo a genetic test for monogenic diabetes. If found to have monogenic diabetes, their diabetes treatment was reviewed and changed as appropriate. The majority of participants had T1DM: of 1875, 131 were found to have T2DM and 60 were found to have some form of MODY.
- Access:
- Open only through collaboration
- Type:
- Disease specific
- Status:
- Completed
- Consent restrictions:
- Other animal work restriction, Xenograft restriction
Associated Data Type | Procurement Timeframe |
---|---|
Biomarker datasets | 0 - 3 months |
Clinical records | 0 - 3 months |
Cold ischemic time | 0 - 3 months |
Followup records | 0 - 3 months |
Freezer temperature logs | 0 - 3 months |
Genomic datasets | 0 - 3 months |
Physiological/biochemical measurements | 0 - 3 months |
Primary care records | 0 - 3 months |
Quality indicators | 0 - 3 months |
Female
Young child (2 - 6 years)
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
DNA | -60°C to -85°C | N/A | Not applicable | 11 - 25% | |
Serum | -60°C to -85°C | N/A | Not applicable | 51 - 75% | |
Urine | -60°C to -85°C | N/A | Not applicable | 100% |