Malignant tumor of rectum (disorder)
ARISTOTLE Trial: Pathology/Tissue Samples
Year Started: 2015
Archival tumour tissue from diagnostic biopsy and tumour tissue & normal mucosal tissue from tumour resection (post CRT) are collected and stored for future translational research.
- Access:
- Access restricted at present
- Type:
- Disease specific
- Status:
- In progress
- Consent restrictions:
- No restrictions
Associated Data Type | Procurement Timeframe |
---|---|
There is no associated data for this collection. |
Female
Young adult (18 - 40 years)
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Tissue specimen | Surgical procedure (procedure) | RT | N/A | Not applicable | 75% -99% |
Female
Adult (> 40 years)
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Tissue specimen | Surgical procedure (procedure) | RT | N/A | Not applicable | 75% -99% |
Malignant tumor of rectum (disorder)
ARISTOTLE Trial: Blood Samples
Year Started: 2015
Whole blood samples will processed to collect: (i) plasma samples at 4 timpoints for circulating tumour DNA (ctDNA): pre-treatment, during weeks 1 and 5 of treatment and during week 10 (after CRT) (ii) buffy coat for germline DNA at any timepoint after recruitment
- Access:
- Access restricted at present
- Type:
- Disease specific
- Status:
- In progress
- Consent restrictions:
- No restrictions
Associated Data Type | Procurement Timeframe |
---|---|
There is no associated data for this collection. |
Female
Young adult (18 - 40 years)
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Peripheral blood mononuclear cells (PBMC) | -60°C to -85°C | N/A | Not applicable | 75% -99% | |
Plasma | -60°C to -85°C | N/A | Not applicable | 51 - 75% |
Female
Adult (> 40 years)
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Peripheral blood mononuclear cells (PBMC) | -60°C to -85°C | N/A | Not applicable | 75% -99% | |
Plasma | -60°C to -85°C | N/A | Not applicable | 51 - 75% |