Malignant tumor of breast (disorder)

Sheffield Collaborating Centre of the Breast Cancer Now Tissue Bank

Year Started: 2013

The University of Sheffield collects malignant and normal breast tissue and blood samples from patients attending the Royal Hallamshire Hospital and Weston Park Hospital, Sheffield as part of a research project led by Prof. Angela Cox; "The role of angiogenesis and genome stability in breast cancer, and biosample collection". The research group specialises in the collection of longitudinal blood samples, including blood plasma for circulating DNA applications. Patients are invited to donate their samples to the Breast Cancer Now Tissue Bank (BCNTB), a ground-breaking, multi-million pound initiative linking five centres around the country which work together as one national resource. The BCNTB represents the UK’s single largest unique collection of high-quality breast tissue samples. Breast Cancer Now Tissue Bank samples are held in the Leeds Breast Research Tissue Bank at St. James University Hospital, a founder member of the BCNTB.



Access:
Open to applicants
Type:
Disease specific
Status:
In progress
Consent restrictions:
No restrictions


Associated Data Type Procurement Timeframe
Clinical records 0 - 3 months
Followup records 0 - 3 months
Freezer temperature logs 0 - 3 months
Pathology records 0 - 3 months
Treatment records 0 - 3 months
Donor Ethnicity 0 - 3 months


Female

Young adult (18 - 40 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
DNA -18°C to -35°C N/A Not applicable 11 - 25%
Peripheral blood mononuclear cells (PBMC) -60°C to -85°C N/A Not applicable 75% -99%
Peripheral blood mononuclear cells (PBMC) Liquid nitrogen liquid phase N/A Not applicable 75% -99%
Plasma -60°C to -85°C N/A Not applicable 75% -99%
Serum -60°C to -85°C N/A Not applicable 26 - 50%
Tissue specimen Surgical procedure (procedure) RT Paraffin Affected 11 - 25%
Tissue specimen Surgical procedure (procedure) RT Paraffin Non-affected 0 - 10%
Whole blood -18°C to -35°C N/A Not applicable 0 - 10%


Female

Adult (> 40 years)

501 - 1000 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
DNA -18°C to -35°C N/A Not applicable 11 - 25%
Peripheral blood mononuclear cells (PBMC) -60°C to -85°C N/A Not applicable 75% -99%
Peripheral blood mononuclear cells (PBMC) Liquid nitrogen liquid phase N/A Not applicable 75% -99%
Plasma -60°C to -85°C N/A Not applicable 51 - 75%
Serum -60°C to -85°C N/A Not applicable 11 - 25%
Tissue specimen Surgical procedure (procedure) RT Paraffin Affected 26 - 50%
Tissue specimen Surgical procedure (procedure) RT Paraffin Non-affected 11 - 25%
Whole blood -18°C to -35°C N/A Not applicable 11 - 25%