Malignant tumor of breast (disorder)
Sheffield Collaborating Centre of the Breast Cancer Now Tissue Bank
Year Started: 2013
The University of Sheffield collects malignant and normal breast tissue and blood samples from patients attending the Royal Hallamshire Hospital and Weston Park Hospital, Sheffield as part of a research project led by Prof. Angela Cox; "The role of angiogenesis and genome stability in breast cancer, and biosample collection". The research group specialises in the collection of longitudinal blood samples, including blood plasma for circulating DNA applications. Patients are invited to donate their samples to the Breast Cancer Now Tissue Bank (BCNTB), a ground-breaking, multi-million pound initiative linking five centres around the country which work together as one national resource. The BCNTB represents the UK’s single largest unique collection of high-quality breast tissue samples. Breast Cancer Now Tissue Bank samples are held in the Leeds Breast Research Tissue Bank at St. James University Hospital, a founder member of the BCNTB.
- Access:
- Open to applicants
- Type:
- Disease specific
- Status:
- In progress
- Consent restrictions:
- No restrictions
Associated Data Type | Procurement Timeframe |
---|---|
Clinical records | 0 - 3 months |
Followup records | 0 - 3 months |
Freezer temperature logs | 0 - 3 months |
Pathology records | 0 - 3 months |
Treatment records | 0 - 3 months |
Donor Ethnicity | 0 - 3 months |
Female
Young adult (18 - 40 years)
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
DNA | -18°C to -35°C | N/A | Not applicable | 11 - 25% | |
Peripheral blood mononuclear cells (PBMC) | -60°C to -85°C | N/A | Not applicable | 75% -99% | |
Peripheral blood mononuclear cells (PBMC) | Liquid nitrogen liquid phase | N/A | Not applicable | 75% -99% | |
Plasma | -60°C to -85°C | N/A | Not applicable | 75% -99% | |
Serum | -60°C to -85°C | N/A | Not applicable | 26 - 50% | |
Tissue specimen | Surgical procedure (procedure) | RT | Paraffin | Affected | 11 - 25% |
Tissue specimen | Surgical procedure (procedure) | RT | Paraffin | Non-affected | 0 - 10% |
Whole blood | -18°C to -35°C | N/A | Not applicable | 0 - 10% |
Female
Adult (> 40 years)
501 - 1000 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
DNA | -18°C to -35°C | N/A | Not applicable | 11 - 25% | |
Peripheral blood mononuclear cells (PBMC) | -60°C to -85°C | N/A | Not applicable | 75% -99% | |
Peripheral blood mononuclear cells (PBMC) | Liquid nitrogen liquid phase | N/A | Not applicable | 75% -99% | |
Plasma | -60°C to -85°C | N/A | Not applicable | 51 - 75% | |
Serum | -60°C to -85°C | N/A | Not applicable | 11 - 25% | |
Tissue specimen | Surgical procedure (procedure) | RT | Paraffin | Affected | 26 - 50% |
Tissue specimen | Surgical procedure (procedure) | RT | Paraffin | Non-affected | 11 - 25% |
Whole blood | -18°C to -35°C | N/A | Not applicable | 11 - 25% |