Rheumatoid arthritis

PEAC: Pathobiology of Early Arthritis Cohort

Year Started: 2008

Prospective, observational study in patients with early symptomatic inflammatory arthritis (http://www.peac-mrc.mds.qmul.ac.uk/). Biological samples (synovial tissue & fluids) are collected at two timepoints - Baseline & Follow-up (6 month), please note figures for baseline samples are represented (6 month sample availability on request). Demographic & clinical data is available & collected at 5 timepoints over a 1-year follow-up period (Baseline, 3, 6, 9 & 12 months). Current recruitment status for Rheumatoid Arthritis cohort is 214 patients (1st April 2019).

Access:
Closed to access
Type:
Cohort
Status:
In progress
Collection point:
Post-diagnosis
Consent restrictions:
Xenograft


Data not recorded

Data not recorded

101 - 500 donors

Material Type Preservation Type Macroscopic Assessment % of Sample Set
Peripheral blood cells Liquid nitrogen Affected 75% -99%
Plasma -60 °C to -85 °C Affected 75% -99%
RNA -60 °C to -85 °C Affected 51 - 75%
Serum -60 °C to -85 °C Affected 75% -99%
Tissue Paraffin Affected 75% -99%
Urine -60 °C to -85 °C Affected 75% -99%

Psoriatic arthritis (disorder)

PEAC: Pathobiology of Early Arthritis Cohort

Year Started: 2008

Prospective, observational study in patients with early symptomatic inflammatory arthritis (http://www.peac-mrc.mds.qmul.ac.uk/). Biological samples (synovial tissue & fluids) are collected at two timepoints - Baseline & Follow-up (6 month), please note figures for baseline samples are represented (6 month sample availability on request). Demographic & clinical data is available & collected at 5 timepoints over a 1-year follow-up period (Baseline, 3, 6, 9 & 12 months). Current recruitment status for Psoriatic Arthritis cohort is 44 patients (1st April 2019).

Access:
Closed to access
Type:
Cohort
Status:
In progress
Collection point:
Post-diagnosis
Consent restrictions:
Xenograft


Data not recorded

Data not recorded

11 - 100 donors

Material Type Preservation Type Macroscopic Assessment % of Sample Set
Peripheral blood cells Liquid nitrogen Affected 75% -99%
Plasma -60 °C to -85 °C Affected 75% -99%
RNA -60 °C to -85 °C Affected 51 - 75%
Serum -60 °C to -85 °C Affected 75% -99%
Tissue Paraffin Affected 75% -99%
Urine -60 °C to -85 °C Affected 75% -99%

Undifferentiated inflammatory arthritis (disorder)

PEAC: Pathobiology of Early Arthritis Cohort

Year Started: 2008

Prospective, observational study in patients with early symptomatic inflammatory arthritis (http://www.peac-mrc.mds.qmul.ac.uk/). Biological samples (synovial tissue & fluids) are collected at two timepoints - Baseline & Follow-up (6 month), please note figures for baseline samples are represented (6 month sample availability on request). Demographic & clinical data is available & collected at 5 timepoints over a 1-year follow-up period (Baseline, 3, 6, 9 & 12 months). Current recruitment status for the Undifferentiated/Non-Inflammatory Arthritis cohort is 65 patients (1st April 2019).

Access:
Closed to access
Type:
Cohort
Status:
In progress
Collection point:
Post-diagnosis
Consent restrictions:
Xenograft


Data not recorded

Data not recorded

11 - 100 donors

Material Type Preservation Type Macroscopic Assessment % of Sample Set
Peripheral blood cells Liquid nitrogen Affected 75% -99%
Plasma -60 °C to -85 °C Affected 75% -99%
RNA -60 °C to -85 °C Affected 51 - 75%
Serum -60 °C to -85 °C Affected 75% -99%
Tissue Paraffin Affected 75% -99%
Urine -60 °C to -85 °C Affected 75% -99%

Rheumatoid arthritis

R4-RA: A Randomised, open labelled study in anti-TNFa inadequate responders to investigate the mechanisms for Response - Resistance to Rituximab versus Tocilizumab in RA

Year Started: 2013

Open-label, randomised controlled clinical trial, multi-centre, multi-country, Phase IV study (http://www.r4ra-nihr.whri.qmul.ac.uk/). Biological samples (synovial tissue & fluids) are collected at multiple timepoints (details available on request), please note figures for baseline samples are represented (availability of samples from other timepoints on request). Demographic & clinical data is available & collected at multiple timepoints over a 2-year follow-up period. Recruitment status for this study is 164 patients.

Access:
Closed to access
Type:
Clinical Trial
Status:
Completed
Collection point:
Post-diagnosis
Consent restrictions:
Xenograft


Data not recorded

Data not recorded

101 - 500 donors

Material Type Preservation Type Macroscopic Assessment % of Sample Set
Peripheral blood cells Liquid nitrogen Affected 75% -99%
Plasma -60 °C to -85 °C Affected 75% -99%
RNA -60 °C to -85 °C Affected 75% -99%
Serum -60 °C to -85 °C Affected 75% -99%
Tissue Paraffin Affected 75% -99%

Rheumatoid arthritis

STRAP: Stratification of Biologic Therapies for RA by Pathobiology. A randomised, open-labelled biopsy-driven stratification trial in DMARD inadequate responder patients randomised to Etanercept, Tocilizumab or Rituximab.

Year Started: 2015

Open-label, randomised controlled clinical trial, multi-centre, multi-country, Phase III study (http://www.matura-mrc.whri.qmul.ac.uk/). Biological samples (synovial tissue & fluids) are collected at multiple timepoints (details available on request), please note figures for baseline samples are represented (availability of samples from other timepoints on request). Demographic & clinical data is available & collected at multiple timepoints over a 2-year follow-up period. Current recruitment status for this study is 200 patients (1st April 2019).

Access:
Closed to access
Type:
Clinical Trial
Status:
In progress
Collection point:
Post-diagnosis
Consent restrictions:
Xenograft


Data not recorded

Data not recorded

101 - 500 donors

Material Type Preservation Type Macroscopic Assessment % of Sample Set
Peripheral blood cells Liquid nitrogen Affected 75% -99%
Plasma -60 °C to -85 °C Affected 75% -99%
RNA -60 °C to -85 °C Affected 75% -99%
Serum -60 °C to -85 °C Affected 75% -99%
Tissue Paraffin Affected 75% -99%

Rheumatoid arthritis

THERAPIST: TH17 Responses Evaluated in RA Patients on Inhibitors of TNFα

Year Started: 2015

Observational, prospective study, multi-centre (http://www.trp-nocri.whri.qmul.ac.uk/). Biological samples (synovial tissue & fluids) collected at multiple timepoints (details available on request), please note figures for baseline samples are represented (availability of samples from other timepoints on request). Tissue available only for patients recruited to the sub-study arm (details available on request). Demographic & clinical data is available & collected at multiple timepoints over a 6 month follow-up period. Recruitment status for this study is 56 patients.

Access:
Closed to access
Type:
Cohort
Status:
Completed
Collection point:
Post-diagnosis
Consent restrictions:
Xenograft


Data not recorded

Data not recorded

11 - 100 donors

Material Type Preservation Type Macroscopic Assessment % of Sample Set
Peripheral blood cells Liquid nitrogen Affected 75% -99%
RNA -60 °C to -85 °C Affected 26 - 50%
Serum -60 °C to -85 °C Affected 75% -99%
Tissue Paraffin Affected 26 - 50%
Urine -60 °C to -85 °C Affected 75% -99%
Whole blood -60 °C to -85 °C Affected 75% -99%

Psoriatic arthritis (disorder)

PSABRE: Psoriatic Arthritis Pathobiology and its Relationship with Clinical Disease Activity

Year Started: 2015

Exploratory, prospective, observational, single site study. To explore the evolution of clinical disease characteristics in patients with psoriatic arthritis who have failed standard non-biologic therapy. Biological samples (synovial & skin tissues, & fluids) collected at multiple timepoints (details available on request), please note figures for baseline samples are represented (availability of samples from other timepoints on request). Demographic & clinical data is available & collected at multiple timepoints over a 48 week follow-up period. Recruitment status for this study is 31 patients.

Access:
Closed to access
Type:
Disease specific
Status:
Completed
Collection point:
Post-diagnosis
Consent restrictions:
Xenograft


Data not recorded

Data not recorded

11 - 100 donors

Material Type Preservation Type Macroscopic Assessment % of Sample Set
Peripheral blood cells Liquid nitrogen Affected 75% -99%
Plasma -60 °C to -85 °C Affected 75% -99%
RNA -60 °C to -85 °C Affected 75% -99%
Serum -60 °C to -85 °C Affected 75% -99%
Tissue Paraffin Affected 75% -99%

Sjögren's syndrome (disorder)

TRACTISS: A randomized double blind placebo controlled clinical TRial of anti-B-Cell Therapy In patients with primary Sjögren’s Syndrome

Year Started: 2011

A multi-centre, randomised, double-blind, placebo controlled, phase III trial in patients with primary Sjögren’s syndrome with fatigue, oral dryness. Males and female recruited between 18 and 80 years of age with an AECG diagnosis of Primary Sjögren’s Syndrome. Biological samples (salivary gland tissue & fluids) collected at multiple timepoints (details available on request) over a 48 week follow-up period; please note figures for baseline samples are represented (availability of samples from other timepoints on request). Recruitment status for this study is 136 patients.

Access:
Closed to access
Type:
Clinical Trial
Status:
Completed
Collection point:
Post-diagnosis
Consent restrictions:
Xenograft


Data not recorded

Data not recorded

101 - 500 donors

Material Type Preservation Type Macroscopic Assessment % of Sample Set
Peripheral blood cells Liquid nitrogen Affected 75% -99%
RNA -60 °C to -85 °C Affected 11 - 25%
Saliva -60 °C to -85 °C Affected 11 - 25%
Serum -60 °C to -85 °C Affected 75% -99%
Tissue Paraffin Affected 11 - 25%

Systemic lupus erythematosus

BHSLE: Sequencing Based Genetic Analysis of Systemic Lupus Erythematosus (SLE)

Year Started: 2015

DNA and clinical information are used to look for similarities and differences between people with SLE and those unaffected by the disease. These data can be used to identify genetic differences that are more common in SLE patients and then ask how these genetic factors affect the immune system and how they influence the nature and severity of the disease. Current recruitment status for this study is 220 patients.

Access:
Closed to access
Type:
Disease specific
Status:
In progress
Collection point:
Post-diagnosis
Consent restrictions:
Xenograft


Data not recorded

Data not recorded

101 - 500 donors

Material Type Preservation Type Macroscopic Assessment % of Sample Set
DNA -60 °C to -85 °C Affected 75% -99%
Peripheral blood cells Liquid nitrogen Affected 51 - 75%
Plasma -60 °C to -85 °C Affected 75% -99%

Rheumatoid arthritis

IRMA: Investigation of the Role of Microbiota in Arthritic Inflammation in DMARD-naïve Early Arthritis patients

Year Started: 2017

Observational, single site study. There are many reports that strongly suggest that certain bacteria living in the mouth and in the intestines of RA patients may cause and/or worsen RA. The purpose of the observational IRMA study is to identify RA patients who also have periodontitis (inflammation in their gums caused by bacteria) and compare them to healthy individuals. We will compare the presence of bacteria in the mouth with the RA disease activity and severity and investigate whether the presence of periodontitis and certain bacteria are related to the inflammation in joints and severity of RA disease. The long term goal is to determine if treating periodontitis, caused by certain bacteria, may help to improve the outcomes for patients with RA. Current recruitment status for this study is 12 patients.

Access:
Closed to access
Type:
Disease specific
Status:
In progress
Collection point:
Post-diagnosis
Consent restrictions:
Xenograft


Data not recorded

Data not recorded

11 - 100 donors

Material Type Preservation Type Macroscopic Assessment % of Sample Set
DNA -60 °C to -85 °C Affected 75% -99%
Faeces -60 °C to -85 °C Affected 75% -99%
Peripheral blood cells Liquid nitrogen Affected 75% -99%
Plasma -60 °C to -85 °C Affected 75% -99%
RNA -60 °C to -85 °C Affected 26 - 50%
Saliva -60 °C to -85 °C Affected 75% -99%
Serum -60 °C to -85 °C Affected 75% -99%
Tissue Paraffin Affected 26 - 50%
Whole blood -60 °C to -85 °C Affected 75% -99%