Psoriatic arthritis (disorder)
PEAC: Pathobiology of Early Arthritis Cohort
Year Started: 2008
Prospective, observational study in patients with early symptomatic inflammatory arthritis (http://www.peac-mrc.mds.qmul.ac.uk/). Biological samples (synovial tissue & fluids) are collected at two timepoints - Baseline & Follow-up (6 month), please note figures for baseline samples are represented (6 month sample availability on request). Demographic & clinical data is available & collected at 5 timepoints over a 1-year follow-up period (Baseline, 3, 6, 9 & 12 months). Current recruitment status for Psoriatic Arthritis cohort is 44 patients (1st April 2019).
- Access:
- Closed to access
- Type:
- Cohort
- Status:
- In progress
- Consent restrictions:
- Xenograft restriction
Associated Data Type | Procurement Timeframe |
---|---|
Biomarker datasets | 0 - 3 months |
Clinical records | 0 - 3 months |
Followup records | 0 - 3 months |
Freezer temperature logs | 0 - 3 months |
Genomic datasets | 0 - 3 months |
Imaging data | 0 - 3 months |
Pathology records | 0 - 3 months |
Physiological/biochemical measurements | 0 - 3 months |
Quality indicators | 0 - 3 months |
Treatment records | 0 - 3 months |
Donor Ethnicity | 0 - 3 months |
Unknown
Data not recorded
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Peripheral blood mononuclear cells (PBMC) | Liquid nitrogen liquid phase | N/A | Affected | 75% -99% | |
Plasma | -60°C to -85°C | N/A | Affected | 75% -99% | |
RNA | -60°C to -85°C | N/A | Affected | 51 - 75% | |
Serum | -60°C to -85°C | N/A | Affected | 75% -99% | |
Tissue specimen | Surgical procedure (procedure) | RT | Paraffin | Affected | 75% -99% |
Urine | -60°C to -85°C | N/A | Affected | 75% -99% |
Undifferentiated inflammatory arthritis (disorder)
PEAC: Pathobiology of Early Arthritis Cohort
Year Started: 2008
Prospective, observational study in patients with early symptomatic inflammatory arthritis (http://www.peac-mrc.mds.qmul.ac.uk/). Biological samples (synovial tissue & fluids) are collected at two timepoints - Baseline & Follow-up (6 month), please note figures for baseline samples are represented (6 month sample availability on request). Demographic & clinical data is available & collected at 5 timepoints over a 1-year follow-up period (Baseline, 3, 6, 9 & 12 months). Current recruitment status for the Undifferentiated/Non-Inflammatory Arthritis cohort is 65 patients (1st April 2019).
- Access:
- Closed to access
- Type:
- Cohort
- Status:
- In progress
- Consent restrictions:
- Xenograft restriction
Associated Data Type | Procurement Timeframe |
---|---|
Biomarker datasets | 0 - 3 months |
Clinical records | 0 - 3 months |
Followup records | 0 - 3 months |
Freezer temperature logs | 0 - 3 months |
Genomic datasets | 0 - 3 months |
Imaging data | 0 - 3 months |
Pathology records | 0 - 3 months |
Quality indicators | 0 - 3 months |
Treatment records | 0 - 3 months |
Donor Ethnicity | 0 - 3 months |
Unknown
Data not recorded
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Peripheral blood mononuclear cells (PBMC) | Liquid nitrogen liquid phase | N/A | Affected | 75% -99% | |
Plasma | -60°C to -85°C | N/A | Affected | 75% -99% | |
RNA | -60°C to -85°C | N/A | Affected | 51 - 75% | |
Serum | -60°C to -85°C | N/A | Affected | 75% -99% | |
Tissue specimen | Surgical procedure (procedure) | RT | Paraffin | Affected | 75% -99% |
Urine | -60°C to -85°C | N/A | Affected | 75% -99% |
Rheumatoid arthritis (disorder)
THERAPIST: TH17 Responses Evaluated in RA Patients on Inhibitors of TNFα
Year Started: 2015
Observational, prospective study, multi-centre (http://www.trp-nocri.whri.qmul.ac.uk/). Biological samples (synovial tissue & fluids) collected at multiple timepoints (details available on request), please note figures for baseline samples are represented (availability of samples from other timepoints on request). Tissue available only for patients recruited to the sub-study arm (details available on request). Demographic & clinical data is available & collected at multiple timepoints over a 6 month follow-up period. Recruitment status for this study is 56 patients.
- Access:
- Closed to access
- Type:
- Cohort
- Status:
- Completed
- Consent restrictions:
- Xenograft restriction
Associated Data Type | Procurement Timeframe |
---|---|
Biomarker datasets | 0 - 3 months |
Clinical records | 0 - 3 months |
Followup records | 0 - 3 months |
Freezer temperature logs | 0 - 3 months |
Imaging data | 0 - 3 months |
Pathology records | 0 - 3 months |
Physiological/biochemical measurements | 0 - 3 months |
Quality indicators | 0 - 3 months |
Treatment records | 0 - 3 months |
Donor Ethnicity | 0 - 3 months |
Unknown
Data not recorded
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Peripheral blood mononuclear cells (PBMC) | Liquid nitrogen liquid phase | N/A | Affected | 75% -99% | |
RNA | -60°C to -85°C | N/A | Affected | 26 - 50% | |
Serum | -60°C to -85°C | N/A | Affected | 75% -99% | |
Tissue specimen | Surgical procedure (procedure) | RT | Paraffin | Affected | 26 - 50% |
Urine | -60°C to -85°C | N/A | Affected | 75% -99% | |
Whole blood | -60°C to -85°C | N/A | Affected | 75% -99% |
Psoriatic arthritis (disorder)
PSABRE: Psoriatic Arthritis Pathobiology and its Relationship with Clinical Disease Activity
Year Started: 2015
Exploratory, prospective, observational, single site study. To explore the evolution of clinical disease characteristics in patients with psoriatic arthritis who have failed standard non-biologic therapy. Biological samples (synovial & skin tissues, & fluids) collected at multiple timepoints (details available on request), please note figures for baseline samples are represented (availability of samples from other timepoints on request). Demographic & clinical data is available & collected at multiple timepoints over a 48 week follow-up period. Recruitment status for this study is 31 patients.
- Access:
- Closed to access
- Type:
- Disease specific
- Status:
- Completed
- Consent restrictions:
- Xenograft restriction
Associated Data Type | Procurement Timeframe |
---|---|
Biomarker datasets | 0 - 3 months |
Clinical records | 0 - 3 months |
Followup records | 0 - 3 months |
Freezer temperature logs | 0 - 3 months |
Imaging data | 0 - 3 months |
Pathology records | 0 - 3 months |
Physiological/biochemical measurements | 0 - 3 months |
Quality indicators | 0 - 3 months |
Treatment records | 0 - 3 months |
Donor Ethnicity | 0 - 3 months |
Unknown
Data not recorded
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Peripheral blood mononuclear cells (PBMC) | Liquid nitrogen liquid phase | N/A | Affected | 75% -99% | |
Plasma | -60°C to -85°C | N/A | Affected | 75% -99% | |
RNA | -60°C to -85°C | N/A | Affected | 75% -99% | |
Serum | -60°C to -85°C | N/A | Affected | 75% -99% | |
Tissue specimen | Surgical procedure (procedure) | RT | Paraffin | Affected | 75% -99% |
Rheumatoid arthritis (disorder)
IRMA: Investigation of the Role of Microbiota in Arthritic Inflammation in DMARD-naïve Early Arthritis patients
Year Started: 2017
Observational, single site study. There are many reports that strongly suggest that certain bacteria living in the mouth and in the intestines of RA patients may cause and/or worsen RA. The purpose of the observational IRMA study is to identify RA patients who also have periodontitis (inflammation in their gums caused by bacteria) and compare them to healthy individuals. We will compare the presence of bacteria in the mouth with the RA disease activity and severity and investigate whether the presence of periodontitis and certain bacteria are related to the inflammation in joints and severity of RA disease. The long term goal is to determine if treating periodontitis, caused by certain bacteria, may help to improve the outcomes for patients with RA. Current recruitment status for this study is 12 patients.
- Access:
- Closed to access
- Type:
- Disease specific
- Status:
- In progress
- Consent restrictions:
- Xenograft restriction
Associated Data Type | Procurement Timeframe |
---|---|
Clinical records | 3 - 6 months |
Freezer temperature logs | 0 - 3 months |
Pathology records | 3 - 6 months |
Physiological/biochemical measurements | 3 - 6 months |
Treatment records | 3 - 6 months |
Donor Ethnicity | 3 - 6 months |
Unknown
Data not recorded
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
DNA | -60°C to -85°C | N/A | Affected | 75% -99% | |
Faeces | -60°C to -85°C | N/A | Affected | 75% -99% | |
Peripheral blood mononuclear cells (PBMC) | Liquid nitrogen liquid phase | N/A | Affected | 75% -99% | |
Plasma | -60°C to -85°C | N/A | Affected | 75% -99% | |
RNA | -60°C to -85°C | N/A | Affected | 26 - 50% | |
Saliva | -60°C to -85°C | N/A | Affected | 75% -99% | |
Serum | -60°C to -85°C | N/A | Affected | 75% -99% | |
Tissue specimen | Surgical procedure (procedure) | RT | Paraffin | Affected | 26 - 50% |
Whole blood | -60°C to -85°C | N/A | Affected | 75% -99% |