Rheumatoid arthritis (disorder)
IRMA: Investigation of the Role of Microbiota in Arthritic Inflammation in DMARD-naïve Early Arthritis patients
Year Started: 2017
Observational, single site study. There are many reports that strongly suggest that certain bacteria living in the mouth and in the intestines of RA patients may cause and/or worsen RA. The purpose of the observational IRMA study is to identify RA patients who also have periodontitis (inflammation in their gums caused by bacteria) and compare them to healthy individuals. We will compare the presence of bacteria in the mouth with the RA disease activity and severity and investigate whether the presence of periodontitis and certain bacteria are related to the inflammation in joints and severity of RA disease. The long term goal is to determine if treating periodontitis, caused by certain bacteria, may help to improve the outcomes for patients with RA. Current recruitment status for this study is 12 patients.
- Access:
- Closed to access
- Type:
- Disease specific
- Status:
- In progress
- Consent restrictions:
- Xenograft restriction
Associated Data Type | Procurement Timeframe |
---|---|
Clinical records | 3 - 6 months |
Freezer temperature logs | 0 - 3 months |
Pathology records | 3 - 6 months |
Physiological/biochemical measurements | 3 - 6 months |
Treatment records | 3 - 6 months |
Donor Ethnicity | 3 - 6 months |
Unknown
Data not recorded
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
DNA | -60°C to -85°C | N/A | Affected | 75% -99% | |
Faeces | -60°C to -85°C | N/A | Affected | 75% -99% | |
Peripheral blood mononuclear cells (PBMC) | Liquid nitrogen liquid phase | N/A | Affected | 75% -99% | |
Plasma | -60°C to -85°C | N/A | Affected | 75% -99% | |
RNA | -60°C to -85°C | N/A | Affected | 26 - 50% | |
Saliva | -60°C to -85°C | N/A | Affected | 75% -99% | |
Serum | -60°C to -85°C | N/A | Affected | 75% -99% | |
Tissue specimen | Surgical procedure (procedure) | RT | Paraffin | Affected | 26 - 50% |
Whole blood | -60°C to -85°C | N/A | Affected | 75% -99% |