Rheumatoid arthritis (disorder)

Scottish Early Rheumatoid Arthritis Study

Year Started: 2011

SERA was a population-wide inception cohort that recruited new onset rheumatoid arthritis patients (RA n=919; Healthy Volunteers n=86) in a routine NHS setting. Clinical characteristics including therapeutics and disease activity parameters were recorded with a broad range of biobanked biological samples (>65,000 samples e.g. DNA, RNA, serum, plasma, urine). SERA is a member of the Immune-Mediated Inflammatory Disease Biobanks in the UK Network. Note: commercial entities may access samples and data only in collaboration with an academic partner. Please also see SERA (UA) entry for details of samples from patients with undifferentiated arthritis.



Access:
Open to applicants
Type:
Cohort
Status:
Completed
Consent restrictions:
No restrictions


Associated Data Type Procurement Timeframe
There is no associated data for this collection.


Female

Young adult (18 - 40 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Plasma -60°C to -85°C N/A Not applicable 100%
RNA -60°C to -85°C N/A Not applicable 75% -99%
Serum -60°C to -85°C N/A Not applicable 100%
Urine -60°C to -85°C N/A Not applicable 75% -99%
Whole blood -60°C to -85°C N/A Not applicable 100%
Dried whole blood (e.g. Guthrie cards) DWB RT N/A Not applicable 75% -99%


Male

Young adult (18 - 40 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Plasma -60°C to -85°C N/A Not applicable 100%
RNA -60°C to -85°C N/A Not applicable 75% -99%
Serum -60°C to -85°C N/A Not applicable 100%
Tissue specimen Surgical procedure (procedure) -60°C to -85°C N/A Not applicable 0 - 10%
Urine -60°C to -85°C N/A Not applicable 75% -99%
Whole blood -60°C to -85°C N/A Not applicable 100%
Dried whole blood (e.g. Guthrie cards) DWB RT N/A Not applicable 75% -99%
Dried whole blood (e.g. Guthrie cards) DWB -60°C to -85°C N/A Not applicable 75% -99%


Female

Adult (> 40 years)

501 - 1000 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Plasma -60°C to -85°C N/A Not applicable 100%
RNA -60°C to -85°C N/A Not applicable 75% -99%
Serum -60°C to -85°C N/A Not applicable 100%
Urine -60°C to -85°C N/A Not applicable 75% -99%
Whole blood -60°C to -85°C N/A Not applicable 100%
Dried whole blood (e.g. Guthrie cards) DWB RT N/A Not applicable 75% -99%
Synovial fluid -60°C to -85°C N/A Not applicable 0 - 10%


Male

Adult (> 40 years)

101 - 500 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Plasma -60°C to -85°C N/A Not applicable 100%
RNA -60°C to -85°C N/A Not applicable 75% -99%
Serum -60°C to -85°C N/A Not applicable 75% -99%
Tissue specimen Surgical procedure (procedure) -60°C to -85°C N/A Not applicable 0 - 10%
Urine -60°C to -85°C N/A Not applicable 75% -99%
Whole blood -60°C to -85°C N/A Not applicable 100%
Dried whole blood (e.g. Guthrie cards) DWB RT N/A Not applicable 75% -99%
Synovial fluid -60°C to -85°C N/A Not applicable 0 - 10%

Undifferentiated inflammatory arthritis (disorder)

Scottish Early Rheumatoid Arthritis (Undifferentiated)

Year Started: 2011

SERA was a population-wide inception cohort that recruited new onset rheumatoid arthritis patients in a routine NHS setting. Clinical characteristics including therapeutics and disease activity parameters were recorded with a broad range of biobanked biological samples (>54,000 samples e.g. DNA, RNA, serum, plasma, urine from 145 individuals). SERA is a member of the Immune-Mediated Inflammatory Disease Biobanks in the UK Network. Note: access to commercial entities is permitted in conjunction with an academic partner.



Access:
Open to applicants
Type:
Disease specific
Status:
Completed
Consent restrictions:
Commercial restriction


Associated Data Type Procurement Timeframe
There is no associated data for this collection.


Female

Young adult (18 - 40 years)

1 - 10 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Plasma -60°C to -85°C N/A Not applicable 75% -99%
RNA -60°C to -85°C N/A Not applicable 51 - 75%
Serum -60°C to -85°C N/A Not applicable 75% -99%
Urine -60°C to -85°C N/A Not applicable 75% -99%
Whole blood -60°C to -85°C N/A Not applicable 100%
Dried whole blood (e.g. Guthrie cards) DWB RT N/A Not applicable 0 - 10%


Female

Adult (> 40 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Plasma -60°C to -85°C N/A Not applicable 100%
RNA -60°C to -85°C N/A Not applicable 100%
Serum -60°C to -85°C N/A Not applicable 100%
Urine -60°C to -85°C N/A Not applicable 75% -99%
Whole blood -60°C to -85°C N/A Not applicable 100%
Dried whole blood (e.g. Guthrie cards) DWB RT N/A Not applicable 100%


Male

Young adult (18 - 40 years)

1 - 10 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Plasma -60°C to -85°C N/A Not applicable 100%
RNA -60°C to -85°C N/A Not applicable 100%
Serum -60°C to -85°C N/A Not applicable 100%
Urine -60°C to -85°C N/A Not applicable 100%
Whole blood -60°C to -85°C N/A Not applicable 100%
Dried whole blood (e.g. Guthrie cards) DWB RT N/A Not applicable 100%


Male

Adult (> 40 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Synovial fluid -60°C to -85°C N/A Not applicable 51 - 75%
Plasma -60°C to -85°C N/A Not applicable 100%
RNA -60°C to -85°C N/A Not applicable 100%
Serum -60°C to -85°C N/A Not applicable 100%
Urine -60°C to -85°C N/A Not applicable 100%
Whole blood -60°C to -85°C N/A Not applicable 100%
Dried whole blood (e.g. Guthrie cards) DWB RT N/A Not applicable 100%