Malignant hypertensive chronic kidney disease (disorder)
NCA020 Renal Collection
Year Started: 2022
This collection consists of serum, whole blood and swabs from patients with kidney disease, including patients with acute kidney injury, glomerulonephritis and polycystic kidney disease. This collection also includes surplus arterial tissue collected from pre-dialysis and dialysis patients during (i) arteriovenous fistula surgery and (ii) limb amputation surgery for peripheral artery disease. Chronic kidney disease is associated with a number of serious complications, including an increased risk of (i) cardiovascular disease (ii) bone forming in the blood vessel wall (vascular calcification) (iii) a reduced red blood cell count (anaemia) (iv) metabolic bone disease There are limited treatment options for some of these serious complications in patients with chronic kidney disease – in particular vascular calcification. This collection will provide a resource for researchers investigating kidney disease and/or vascular complications in kidney disease, and will help researchers understand if the levels and/or activity of specific proteins are changed in this disease. This collection of samples could also be used in improving our understanding of the pathophysiology of kidney diseases (including longitudinal samples). The biological samples collected will enable a number of different analyses to be performed. This may include (but is not limited to): Genetic studies Immunological studies Multi-morbidity studies Biomarker studies Functional analysis of cells – surplus tissue collection from surgery in patients with kidney disease (such as peritoneal catheter insertion, arterio-venous fistula creation, parathyroidectomy)
- Access:
- Open to applicants
- Type:
- Disease specific
- Status:
- In progress
- Consent restrictions:
- Other animal work restriction, Xenograft restriction
Associated Data Type | Procurement Timeframe |
---|---|
Clinical records | 0 - 3 months |
Followup records | 0 - 3 months |
Freezer temperature logs | 0 - 3 months |
Imaging data | 0 - 3 months |
Pathology records | 0 - 3 months |
Primary care records | 0 - 3 months |
Survey data | 0 - 3 months |
Treatment records | 0 - 3 months |
Warm ischemic time | 0 - 3 months |
Donor Ethnicity | 0 - 3 months |
Male
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | Not applicable | 100% | ||
Serum | -60°C to -85°C | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% | ||
Urine | -60°C to -85°C | Not applicable | 100% | ||
Swab | -60°C to -85°C | Not applicable | 100% | ||
Tissue specimen | -60°C to -85°C | Not applicable | 26 - 50% |
Female
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | Not applicable | 100% | ||
Serum | -60°C to -85°C | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% | ||
Urine | -60°C to -85°C | Not applicable | 100% | ||
Swab | -60°C to -85°C | Not applicable | 100% | ||
Tissue specimen | -60°C to -85°C | Not applicable | 26 - 50% |
Mitochondrial cytopathy (disorder)
NCA021 - Inherited Metabolic Diseases Collection
Year Started: 2022
The Northern Care Alliance Research Collection (NCARC) includes a biobank to explore novel application of laboratory biomarkers in Inherited Metabolic Diseases. The collection population comprises patients with rare metabolic diseases such as Mucopolysaccharidosis, Alpha-Mannosidosis, Mucolipidosis, Pompe Disease, Fabry Disease, Gaucher Disease, Phenylketonuria, Urea Cycle Disorders, Organic Acidaemia, mitochondrial diseases and many others. The collection consists of whole blood, serum, plasma and citrate plasma samples as well as associated clinical data from both primary and secondary care settings. The collection allows scope for adjustment to the sample type through NCARC’s simple amendment process. This collection aims to promote biomedical research by providing biomaterial to academic and commercial researchers/partners to facilitate high-quality research in establishing prognostic markers of cardiovascular disease, bone health, renal disease and acute illness among rare diseases. There is potential to improve the method and time taken for diagnosis, prognostication and treatment monitoring with refinement of laboratory processing and biomarker discovery. Our biological samples have been processed and stored under conditions that reflect the current best practise to maximise the integrity and security of the samples and ensure compliance with current regulatory requirements. The biological samples collected will enable a number of different analyses to be performed. This may include (but not limited to): • Biomarker studies • Multi-morbidity studies • Biomedical device development
- Access:
- Open to applicants
- Type:
- Disease specific
- Status:
- In progress
- Consent restrictions:
- Other animal work restriction, Xenograft restriction
Associated Data Type | Procurement Timeframe |
---|---|
Clinical records | 0 - 3 months |
Followup records | 0 - 3 months |
Freezer temperature logs | 0 - 3 months |
Imaging data | 0 - 3 months |
Pathology records | 0 - 3 months |
Primary care records | 0 - 3 months |
Survey data | 0 - 3 months |
Treatment records | 0 - 3 months |
Warm ischemic time | 0 - 3 months |
Donor Ethnicity | 0 - 3 months |
Male
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | Not applicable | 100% | ||
Serum | -60°C to -85°C | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% | ||
Urine | -60°C to -85°C | Not applicable | 100% | ||
Swab | -60°C to -85°C | Not applicable | 100% | ||
Tissue specimen | -60°C to -85°C | Not applicable | 26 - 50% |
Female
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | Not applicable | 100% | ||
Serum | -60°C to -85°C | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% | ||
Urine | -60°C to -85°C | Not applicable | 100% | ||
Swab | -60°C to -85°C | Not applicable | 100% | ||
Tissue specimen | -60°C to -85°C | Not applicable | 26 - 50% |
Acute coronary syndrome (disorder)
NCA015 - Blood Biomarkers in Acute Cardiovascular Presentations Collection
Year Started: 2021
The acute biobank collection can support explorations of novel application of laboratory biomarkers in acute medical care. The population is acute medical presentations to secondary care. Examples of areas currently in exploration are acute cardiovascular presentations and acute kidney injury. The collection consists of whole blood, serum, plasma and citrate plasma samples and associated clinical data. The collection has scope for adjustment to the sample type collection through NCARC’s simple amendment process. This collection aims to promote biomedical research by providing biomaterial to academic and commercial researchers/partners to facilitate high-quality research in establishing a clear diagnosis in patients presenting to hospitals. There is potential to improve the method and time taken for diagnosis with refinement of laboratory processing and biomarker discovery. The biological samples collected will enable a number of different analyses to be performed. This may include (but is not limited to): • Biomarker studies • Immunological studies • Multi-morbidity studies
- Access:
- Open to applicants
- Type:
- Disease specific
- Status:
- In progress
- Consent restrictions:
- Other animal work restriction, Xenograft restriction
Associated Data Type | Procurement Timeframe |
---|---|
Clinical records | 0 - 3 months |
Followup records | 0 - 3 months |
Freezer temperature logs | 0 - 3 months |
Imaging data | 0 - 3 months |
Pathology records | 0 - 3 months |
Primary care records | 0 - 3 months |
Survey data | 0 - 3 months |
Treatment records | 0 - 3 months |
Warm ischemic time | 0 - 3 months |
Donor Ethnicity | 0 - 3 months |
Female
Adult (> 40 years)
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | Not applicable | 100% | ||
Serum | -60°C to -85°C | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% | ||
Urine | -60°C to -85°C | Not applicable | 100% | ||
Swab | -60°C to -85°C | Not applicable | 100% | ||
Tissue specimen | -60°C to -85°C | Not applicable | 26 - 50% |
Male
Adult (> 40 years)
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | Not applicable | 100% | ||
Serum | -60°C to -85°C | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% | ||
Urine | -60°C to -85°C | Not applicable | 100% | ||
Swab | -60°C to -85°C | Not applicable | 100% | ||
Tissue specimen | -60°C to -85°C | Not applicable | 26 - 50% |
Acquired hypothyroidism (disorder)
NCA018 - Diabetes and Endocrine Collection
Year Started: 2022
The diabetes and endocrine collection of serum, whole blood and swabs from patients with diabetic foot ulcerswill provide an important resource for endocrine, diabetic and testosterone replacement research in the future that has the potential to benefit patients with rare manifestations of diabetes and endocrine disorders. At the NCA we see many patients with rare endocrine conditions such as Congenital Adrenal Hyperplasia, Conn’s Syndrome and Premature Ovarian Failure as well as people who have not responded to the usual treatment approach, such as those with treatment unresponsive hypothyroidism and severe polycystic ovarian syndrome. This collection aims to provide a genetic and serological repository that will be available for academic and commercial research teams to undertake studies so that we can better understand the aetiology and potential optimal therapeutic strategies for managing these conditions. The biological samples collected will enable a number of different analyses to be performed. This may include (but is not limited to): Genetic studies Biomarker studies Functional analysis of cells
- Access:
- Open to applicants
- Type:
- Disease specific
- Status:
- In progress
- Consent restrictions:
- Other animal work restriction, Xenograft restriction
Associated Data Type | Procurement Timeframe |
---|---|
Clinical records | 0 - 3 months |
Followup records | 0 - 3 months |
Freezer temperature logs | 0 - 3 months |
Imaging data | 0 - 3 months |
Pathology records | 0 - 3 months |
Primary care records | 0 - 3 months |
Survey data | 0 - 3 months |
Treatment records | 0 - 3 months |
Warm ischemic time | 0 - 3 months |
Donor Ethnicity | 0 - 3 months |
Male
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | Not applicable | 100% | ||
Serum | -60°C to -85°C | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% | ||
Swab | -60°C to -85°C | Not applicable | 100% | ||
Tissue specimen | -60°C to -85°C | Not applicable | 26 - 50% |
Female
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | Not applicable | 100% | ||
Serum | -60°C to -85°C | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% | ||
Swab | -60°C to -85°C | Not applicable | 100% | ||
Tissue specimen | -60°C to -85°C | Not applicable | 26 - 50% |
Psychoactive substance-induced organic dementia (disorder)
NCA019 - Neurodegenerative Dementias
Year Started: 2022
The neurodegenerative dementias collection of serum, whole blood and swabs from patients with neurodegenerative diseases could be used in improving our understanding of the genetic basis of neurodegenerative diseases, for example those causing dementia. In addition, the samples could support the development of blood biomarker technology with the aim of earlier and more accurate diagnosis of these disorders. Biomarkers may also be developed that allow tracking of disease progression with time – samples collected from the same individuals over various time intervals can support such work (longitudinal samples). At NCA we see many patients with neurodegenerative diseases, many of them will be at relatively early stage of their illness. CFU medical and psychology staff are well-practiced in participant recruitment for research, including dementia studies, and have considerable experience in consenting participants who lack capacity. They can identify suitable individuals and assess capacity. Potentially suitable participants who lack capacity to decide on inclusion in the project can be recruited using a consultee consent form. The biological samples collected will enable a number of different analyses to be performed. This may include (but not limited to): Genetic studies Biomarker studies Functional analysis of cells
- Access:
- Open to applicants
- Type:
- Disease specific
- Status:
- In progress
- Consent restrictions:
- Other animal work restriction, Xenograft restriction
Associated Data Type | Procurement Timeframe |
---|---|
Clinical records | 0 - 3 months |
Followup records | 0 - 3 months |
Freezer temperature logs | 0 - 3 months |
Imaging data | 0 - 3 months |
Pathology records | 0 - 3 months |
Primary care records | 0 - 3 months |
Survey data | 0 - 3 months |
Treatment records | 0 - 3 months |
Warm ischemic time | 0 - 3 months |
Donor Ethnicity | 0 - 3 months |
Female
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | Not applicable | 100% | ||
Serum | -60°C to -85°C | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% | ||
Swab | -60°C to -85°C | Not applicable | 100% |
Male
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | Not applicable | 100% | ||
Serum | -60°C to -85°C | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% | ||
Swab | -60°C to -85°C | Not applicable | 100% |
COVID-19
NCA009 Covid-19 Collection
Year Started: 2020
The Covid-19 collection consists of blood, serum, saliva, sputum, nasal strips, nasopharyngeal & oropharyngeal swabs and pleural fluid from patients infected with the novel coronavirus. In some cases, longitudinal samples have and will be collected, which could include samples prior to or after infections with Covid-19. The Covid-19 collection aims to promote biomedical research by providing biomaterial to academic and commercial researchers/partners to facilitate high-quality research to answer a range of questions including: • How does Covid-19 make some people severely unwell? • Does our immune system protect us from re-infection with COVID-19 after we have recovered from infection? • How well do tests for Covid-19 work? • What are the best ways to identify or test for Covid-19? • How does the body respond throughout the course of infection, recovery and possible reinfection? • How long does our immune system protects us from re-infection with Covid-19 after we have recovered from infection? • How does the immune system contribute to long-term post viral symptoms? The biological samples collected will enable a number of different analyses to be performed. This may include (but is not limited to): • The effects of long Covid-19 • Biomarker studies • Immunological studies • Multi-morbidity studies • Functional analysis of cells of the respiratory system
- Access:
- Open to applicants
- Type:
- Disease specific
- Status:
- In progress
- Consent restrictions:
- Other animal work restriction, Xenograft restriction
Associated Data Type | Procurement Timeframe |
---|---|
Clinical records | 0 - 3 months |
Followup records | 0 - 3 months |
Freezer temperature logs | 0 - 3 months |
Imaging data | 0 - 3 months |
Pathology records | 0 - 3 months |
Primary care records | 0 - 3 months |
Survey data | 0 - 3 months |
Treatment records | 0 - 3 months |
Warm ischemic time | 0 - 3 months |
Donor Ethnicity | 0 - 3 months |
Female
Adult (> 40 years)
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | Not applicable | 100% | ||
Serum | -60°C to -85°C | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% | ||
Swab | -60°C to -85°C | Not applicable | 100% | ||
Saliva | -60°C to -85°C | Not applicable | 75% -99% | ||
Pleural fluid PFL | -60°C to -85°C | Not applicable | 75% -99% | ||
Sputum | -60°C to -85°C | Not applicable | 75% -99% | ||
Cerebrospinal fluid | -60°C to -85°C | Not applicable | 11 - 25% |
Male
Adult (> 40 years)
11 - 100 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | Not applicable | 100% | ||
Serum | -60°C to -85°C | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% | ||
Swab | -60°C to -85°C | Not applicable | 100% | ||
Saliva | -60°C to -85°C | Not applicable | 75% -99% | ||
Pleural fluid PFL | -60°C to -85°C | Not applicable | 75% -99% | ||
Sputum | -60°C to -85°C | Not applicable | 75% -99% | ||
Cerebrospinal fluid | -60°C to -85°C | Not applicable | 11 - 25% |
Mucopolysaccharidosis (disorder)
NCA021 - Inherited Metabolic Diseases Collection
Year Started: 2022
The Northern Care Alliance Research Collection (NCARC) includes a biobank to explore novel application of laboratory biomarkers in Inherited Metabolic Diseases. The collection population comprises patients with rare metabolic diseases such as Mucopolysaccharidosis, Alpha-Mannosidosis, Mucolipidosis, Pompe Disease, Fabry Disease, Gaucher Disease, Phenylketonuria, Urea Cycle Disorders, Organic Acidaemia, mitochondrial diseases and many others. The collection consists of whole blood, serum, plasma and citrate plasma samples as well as associated clinical data from both primary and secondary care settings. The collection allows scope for adjustment to the sample type through NCARC’s simple amendment process. This collection aims to promote biomedical research by providing biomaterial to academic and commercial researchers/partners to facilitate high-quality research in establishing prognostic markers of cardiovascular disease, bone health, renal disease and acute illness among rare diseases. There is potential to improve the method and time taken for diagnosis, prognostication and treatment monitoring with refinement of laboratory processing and biomarker discovery. Our biological samples have been processed and stored under conditions that reflect the current best practise to maximise the integrity and security of the samples and ensure compliance with current regulatory requirements. The biological samples collected will enable a number of different analyses to be performed. This may include (but not limited to): • Biomarker studies • Multi-morbidity studies • Biomedical device development
- Access:
- Open to applicants
- Type:
- Disease specific
- Status:
- In progress
- Consent restrictions:
- No restrictions
Associated Data Type | Procurement Timeframe |
---|---|
Clinical records | 0 - 3 months |
Followup records | 0 - 3 months |
Freezer temperature logs | 0 - 3 months |
Imaging data | 0 - 3 months |
Pathology records | 0 - 3 months |
Primary care records | 0 - 3 months |
Survey data | 0 - 3 months |
Treatment records | 0 - 3 months |
Warm ischemic time | 0 - 3 months |
Donor Ethnicity | 0 - 3 months |
Male
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | Not applicable | 100% | ||
Serum | -60°C to -85°C | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% | ||
Urine | -60°C to -85°C | Not applicable | 100% | ||
Swab | -60°C to -85°C | Not applicable | 100% | ||
Tissue specimen | -60°C to -85°C | Not applicable | 26 - 50% |
Female
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | Not applicable | 100% | ||
Serum | -60°C to -85°C | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% | ||
Urine | -60°C to -85°C | Not applicable | 100% | ||
Swab | -60°C to -85°C | Not applicable | 100% | ||
Tissue specimen | -60°C to -85°C | Not applicable | 26 - 50% |
Mucolipidosis (disorder)
NCA021 - Inherited Metabolic Diseases Collection
Year Started: 2022
The Northern Care Alliance Research Collection (NCARC) includes a biobank to explore novel application of laboratory biomarkers in Inherited Metabolic Diseases. The collection population comprises patients with rare metabolic diseases such as Mucopolysaccharidosis, Alpha-Mannosidosis, Mucolipidosis, Pompe Disease, Fabry Disease, Gaucher Disease, Phenylketonuria, Urea Cycle Disorders, Organic Acidaemia, mitochondrial diseases and many others. The collection consists of whole blood, serum, plasma and citrate plasma samples as well as associated clinical data from both primary and secondary care settings. The collection allows scope for adjustment to the sample type through NCARC’s simple amendment process. This collection aims to promote biomedical research by providing biomaterial to academic and commercial researchers/partners to facilitate high-quality research in establishing prognostic markers of cardiovascular disease, bone health, renal disease and acute illness among rare diseases. There is potential to improve the method and time taken for diagnosis, prognostication and treatment monitoring with refinement of laboratory processing and biomarker discovery. Our biological samples have been processed and stored under conditions that reflect the current best practise to maximise the integrity and security of the samples and ensure compliance with current regulatory requirements. The biological samples collected will enable a number of different analyses to be performed. This may include (but not limited to): • Biomarker studies • Multi-morbidity studies • Biomedical device development
- Access:
- Open to applicants
- Type:
- Disease specific
- Status:
- In progress
- Consent restrictions:
- No restrictions
Associated Data Type | Procurement Timeframe |
---|---|
Clinical records | 0 - 3 months |
Followup records | 0 - 3 months |
Freezer temperature logs | 0 - 3 months |
Imaging data | 0 - 3 months |
Pathology records | 0 - 3 months |
Primary care records | 0 - 3 months |
Survey data | 0 - 3 months |
Treatment records | 0 - 3 months |
Warm ischemic time | 0 - 3 months |
Donor Ethnicity | 0 - 3 months |
Male
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | Not applicable | 100% | ||
Serum | -60°C to -85°C | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% | ||
Urine | -60°C to -85°C | Not applicable | 100% | ||
Swab | -60°C to -85°C | Not applicable | 100% | ||
Tissue specimen | -60°C to -85°C | Not applicable | 26 - 50% |
Female
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | Not applicable | 100% | ||
Serum | -60°C to -85°C | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% | ||
Urine | -60°C to -85°C | Not applicable | 100% | ||
Swab | -60°C to -85°C | Not applicable | 100% | ||
Tissue specimen | -60°C to -85°C | Not applicable | 26 - 50% |
Fabry's disease (disorder)
NCA021 - Inherited Metabolic Diseases Collection
Year Started: 2022
The Northern Care Alliance Research Collection (NCARC) includes a biobank to explore novel application of laboratory biomarkers in Inherited Metabolic Diseases. The collection population comprises patients with rare metabolic diseases such as Mucopolysaccharidosis, Alpha-Mannosidosis, Mucolipidosis, Pompe Disease, Fabry Disease, Gaucher Disease, Phenylketonuria, Urea Cycle Disorders, Organic Acidaemia, mitochondrial diseases and many others. The collection consists of whole blood, serum, plasma and citrate plasma samples as well as associated clinical data from both primary and secondary care settings. The collection allows scope for adjustment to the sample type through NCARC’s simple amendment process. This collection aims to promote biomedical research by providing biomaterial to academic and commercial researchers/partners to facilitate high-quality research in establishing prognostic markers of cardiovascular disease, bone health, renal disease and acute illness among rare diseases. There is potential to improve the method and time taken for diagnosis, prognostication and treatment monitoring with refinement of laboratory processing and biomarker discovery. Our biological samples have been processed and stored under conditions that reflect the current best practise to maximise the integrity and security of the samples and ensure compliance with current regulatory requirements. The biological samples collected will enable a number of different analyses to be performed. This may include (but not limited to): • Biomarker studies • Multi-morbidity studies • Biomedical device development
- Access:
- Open to applicants
- Type:
- Disease specific
- Status:
- In progress
- Consent restrictions:
- No restrictions
Associated Data Type | Procurement Timeframe |
---|---|
Clinical records | 0 - 3 months |
Followup records | 0 - 3 months |
Freezer temperature logs | 0 - 3 months |
Imaging data | 0 - 3 months |
Pathology records | 0 - 3 months |
Primary care records | 0 - 3 months |
Survey data | 0 - 3 months |
Treatment records | 0 - 3 months |
Warm ischemic time | 0 - 3 months |
Donor Ethnicity | 0 - 3 months |
Male
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | Not applicable | 100% | ||
Serum | -60°C to -85°C | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% | ||
Urine | -60°C to -85°C | Not applicable | 100% | ||
Swab | -60°C to -85°C | Not applicable | 100% | ||
Tissue specimen | -60°C to -85°C | Not applicable | 26 - 50% |
Female
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | Not applicable | 100% | ||
Serum | -60°C to -85°C | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% | ||
Urine | -60°C to -85°C | Not applicable | 100% | ||
Swab | -60°C to -85°C | Not applicable | 100% | ||
Tissue specimen | -60°C to -85°C | Not applicable | 26 - 50% |
Organic Acidaemia (disorder)
NCA021 - Inherited Metabolic Diseases Collection
Year Started: 2022
The Northern Care Alliance Research Collection (NCARC) includes a biobank to explore novel application of laboratory biomarkers in Inherited Metabolic Diseases. The collection population comprises patients with rare metabolic diseases such as Mucopolysaccharidosis, Alpha-Mannosidosis, Mucolipidosis, Pompe Disease, Fabry Disease, Gaucher Disease, Phenylketonuria, Urea Cycle Disorders, Organic Acidaemia, mitochondrial diseases and many others. The collection consists of whole blood, serum, plasma and citrate plasma samples as well as associated clinical data from both primary and secondary care settings. The collection allows scope for adjustment to the sample type through NCARC’s simple amendment process. This collection aims to promote biomedical research by providing biomaterial to academic and commercial researchers/partners to facilitate high-quality research in establishing prognostic markers of cardiovascular disease, bone health, renal disease and acute illness among rare diseases. There is potential to improve the method and time taken for diagnosis, prognostication and treatment monitoring with refinement of laboratory processing and biomarker discovery. Our biological samples have been processed and stored under conditions that reflect the current best practise to maximise the integrity and security of the samples and ensure compliance with current regulatory requirements. The biological samples collected will enable a number of different analyses to be performed. This may include (but not limited to): • Biomarker studies • Multi-morbidity studies • Biomedical device development
- Access:
- Open to applicants
- Type:
- Disease specific
- Status:
- In progress
- Consent restrictions:
- No restrictions
Associated Data Type | Procurement Timeframe |
---|---|
Clinical records | 0 - 3 months |
Followup records | 0 - 3 months |
Freezer temperature logs | 0 - 3 months |
Imaging data | 0 - 3 months |
Pathology records | 0 - 3 months |
Primary care records | 0 - 3 months |
Survey data | 0 - 3 months |
Treatment records | 0 - 3 months |
Warm ischemic time | 0 - 3 months |
Donor Ethnicity | 0 - 3 months |
Male
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | Not applicable | 100% | ||
Serum | -60°C to -85°C | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% | ||
Urine | -60°C to -85°C | Not applicable | 100% | ||
Swab | -60°C to -85°C | Not applicable | 100% | ||
Tissue specimen | -60°C to -85°C | Not applicable | 26 - 50% |
Female
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Whole blood | -60°C to -85°C | Not applicable | 100% | ||
Serum | -60°C to -85°C | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% | ||
Urine | -60°C to -85°C | Not applicable | 100% | ||
Swab | -60°C to -85°C | Not applicable | 100% | ||
Tissue specimen | -60°C to -85°C | Not applicable | 26 - 50% |