Malignant lymphoma (disorder)
PROSECO - A UK multicentre prospective observational study evaluating COVID-19 vaccine immune responses in lymphoid cancer
Year Started: 2021
Population-wide prophylactic vaccination is the principal means of quelling the COVID-19 pandemic. For this to succeed, knowledge of vaccine efficacy is imperative. Patients with lymphoid malignancies have an increased mortality risk from COVID-19. Many patients are apparently cured but have long-term immune defects. Our lack of knowledge of COVID-19 vaccination responses confers a morbidity and mortality risk in this population and significant societal impact. This study will assess COVID-19 vaccine efficacy defined by immunological responses (anti-spike IgG, virus neutralisation, T-cell recall).
- Access:
- Access restricted at present
- Type:
- Disease specific
- Status:
- In progress
- Consent restrictions:
- Commercial restriction, Xenograft restriction
Associated Data Type | Procurement Timeframe |
---|---|
Biomarker datasets | > 6 months |
Clinical records | > 6 months |
Followup records | > 6 months |
Freezer temperature logs | > 6 months |
Genomic datasets | > 6 months |
Pathology records | > 6 months |
Physiological/biochemical measurements | > 6 months |
Quality indicators | > 6 months |
Treatment records | > 6 months |
Donor Ethnicity | > 6 months |
Female
Young adult (18 - 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Peripheral blood mononuclear cells (PBMC) | Liquid nitrogen vapor phase | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% |
Male
Young adult (18 - 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Peripheral blood mononuclear cells (PBMC) | Liquid nitrogen vapor phase | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% |
Female
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Peripheral blood mononuclear cells (PBMC) | Liquid nitrogen vapor phase | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% |
Male
Adult (> 40 years)
1 - 10 donors
Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
---|---|---|---|---|---|
Peripheral blood mononuclear cells (PBMC) | Liquid nitrogen vapor phase | Not applicable | 100% | ||
Plasma | -60°C to -85°C | Not applicable | 100% |