COVID-19
REACT Observational Study of COVID-19
Year Started: 2020
SARS-CoV-2 has emerged as a global pandemic in 2020. There are no effective treatments and an effective vaccine has not been developed. Whilst many patients recover without need for hospitalisation, a small proportion go on to develop severe disease. A better understanding of the natural history of this disease will facilitate improved clinical management with the potential to identify options for intervention.
This proposal is for the formal collection of characterisation data for patients tested for and/or admitted with a confirmed diagnosis of SARS-CoV-2 infection. This study responds to the need for a clear understanding of the natural history of this novel, emerging pandemic. Specifically phenotypic characterisation may enable application of personalised medical approaches, based on clinical course, to aid earlier identification of patients at risk of severe disease, and facilitate identification of potential targets for novel treatments. The collection and characterisation of these patients reflects a strong partnership between NHS and academic critical care and respiratory medicine in Southampton that acts as both a secondary and tertiary centre, with support from the digital experimental cancer medicine team at the University of Manchester.
- Access:
- Access restricted at present
- Type:
- Disease specific
- Status:
- In progress
- Consent restrictions:
-
Commercial restriction, Xenograft restriction
Associated Data Type |
Procurement Timeframe |
Biomarker datasets |
> 6 months |
Clinical records |
> 6 months |
Followup records |
> 6 months |
Freezer temperature logs |
> 6 months |
Pathology records |
> 6 months |
Physiological/biochemical measurements |
> 6 months |
Quality indicators |
> 6 months |
Treatment records |
> 6 months |
Donor Ethnicity |
> 6 months |
Male
Young adult (18 - 40 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Serum |
|
-60°C to -85°C |
|
Not applicable |
51 - 75% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Swab |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Saliva |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
0 - 10% |
Urine |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Male
Adolescent (12 - 18 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Serum |
|
-60°C to -85°C |
|
Not applicable |
51 - 75% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Swab |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Saliva |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
0 - 10% |
Urine |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Male
Child (6 - 12 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Serum |
|
-60°C to -85°C |
|
Not applicable |
51 - 75% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Swab |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Saliva |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
0 - 10% |
Urine |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Male
Adult (> 40 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Serum |
|
-60°C to -85°C |
|
Not applicable |
51 - 75% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Swab |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Saliva |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
0 - 10% |
Urine |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Female
Young adult (18 - 40 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Serum |
|
-60°C to -85°C |
|
Not applicable |
51 - 75% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Swab |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Saliva |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
0 - 10% |
Urine |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Female
Young child (2 - 6 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Serum |
|
-60°C to -85°C |
|
Not applicable |
51 - 75% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Swab |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Saliva |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
0 - 10% |
Urine |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Female
Adolescent (12 - 18 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Serum |
|
-60°C to -85°C |
|
Not applicable |
51 - 75% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Swab |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Saliva |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
0 - 10% |
Urine |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Female
Infant (1 month - 2 years)
1 - 10 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Serum |
|
-60°C to -85°C |
|
Not applicable |
51 - 75% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Swab |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Saliva |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
0 - 10% |
Urine |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Male
Young child (2 - 6 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Serum |
|
-60°C to -85°C |
|
Not applicable |
51 - 75% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Swab |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Saliva |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
0 - 10% |
Urine |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Male
Infant (1 month - 2 years)
1 - 10 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Serum |
|
-60°C to -85°C |
|
Not applicable |
51 - 75% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Swab |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Saliva |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
0 - 10% |
Urine |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Female
Child (6 - 12 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Serum |
|
-60°C to -85°C |
|
Not applicable |
51 - 75% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Swab |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Saliva |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
0 - 10% |
Urine |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Female
Adult (> 40 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Serum |
|
-60°C to -85°C |
|
Not applicable |
51 - 75% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Swab |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Saliva |
|
-60°C to -85°C |
|
Not applicable |
11 - 25% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
0 - 10% |
Urine |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
0 - 10% |
Fit and well (finding)
Isolation of peripheral blood mononuclear cells (PBMC) from whole blood donated by healthy volunteers for laboratory certification purposes
Year Started: 2017
Due to increasing demand for the validation of staff performing white blood cell isolation from whole blood, laboratory operators based in the University of Southampton and University Hospital Southampton NHS Foundation Trust must be certified by conducting the activities described in specific standard operating procedures (SOPs) for the separation of white blood cells from whole blood. In order to validate the laboratory operators for the purpose of certification, blood from healthy volunteers is required. The isolated white cells will undergo analysis to determine how many cells were isolated, if the cells are dead or alive and if the cells have been excessively stimulated during the procedure or not. If there are any cells left over after the analysis has been done, they will be destroyed. If the quantity and quality of the white blood cells falls within expected parameters, the operators performing the procedure will be validated and certified for that particular SOP.
- Access:
- Access restricted at present
- Type:
- Cohort
- Status:
- In progress
- Consent restrictions:
-
Commercial restriction, Xenograft restriction
Associated Data Type |
Procurement Timeframe |
Biomarker datasets |
> 6 months |
Clinical records |
> 6 months |
Freezer temperature logs |
> 6 months |
Physiological/biochemical measurements |
> 6 months |
Quality indicators |
> 6 months |
Donor Ethnicity |
> 6 months |
Female
Adult (> 40 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
100% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
100% |
Female
Young adult (18 - 40 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
100% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
100% |
Male
Young adult (18 - 40 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
100% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
100% |
Male
Adult (> 40 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
100% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
100% |
Fit and well (finding)
An RNAseq study of SARS-CoV2 viral entry routes, disease biomarkers and therapeutic targets in the eye
Year Started: 2020
SARS-CoV2 is the virus which causes COVID-19, the form of coronavirus which is now a global pandemic. The gene ACE2 is involved when SARS-CoV2 infection occurs and the eye is an important possible place of entry for the virus to get into the body. It is thought that the virus enters the eye through ACE2, but this remains unclear. We will look at gene expression in eye tissue to identify whether ACE2 is important in the eye and generate a picture of biomarkers of the eye which may predict disease severity. This will help in understanding the first steps in the mechanism of infection and potential targets for therapies. We will be using excess surgical tissue from the eyes of non COVID-19 patients undergoing surgery for other reasons.
- Access:
- Access restricted at present
- Type:
- Cohort
- Status:
- In progress
- Consent restrictions:
-
Commercial restriction, Xenograft restriction
Associated Data Type |
Procurement Timeframe |
Biomarker datasets |
> 6 months |
Clinical records |
> 6 months |
Genomic datasets |
> 6 months |
Physiological/biochemical measurements |
> 6 months |
Quality indicators |
> 6 months |
Donor Ethnicity |
> 6 months |
Female
Young adult (18 - 40 years)
1 - 10 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Tissue specimen |
|
-60°C to -85°C |
|
Not applicable |
100% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
100% |
Male
Young adult (18 - 40 years)
1 - 10 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Tissue specimen |
|
-60°C to -85°C |
|
Not applicable |
100% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
100% |
Male
Adolescent (12 - 18 years)
1 - 10 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Tissue specimen |
|
-60°C to -85°C |
|
Not applicable |
100% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
100% |
Male
Child (6 - 12 years)
1 - 10 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Tissue specimen |
|
-60°C to -85°C |
|
Not applicable |
100% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
100% |
Female
Adult (> 40 years)
1 - 10 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Tissue specimen |
|
-60°C to -85°C |
|
Not applicable |
100% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
100% |
Male
Adult (> 40 years)
1 - 10 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Tissue specimen |
|
-60°C to -85°C |
|
Not applicable |
100% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
100% |
Female
Adolescent (12 - 18 years)
1 - 10 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Tissue specimen |
|
-60°C to -85°C |
|
Not applicable |
100% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
100% |
Female
Child (6 - 12 years)
1 - 10 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Tissue specimen |
|
-60°C to -85°C |
|
Not applicable |
100% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
100% |
COVID-19
UKRI COVID Immunology consortium: optimal cellular assays for COVID-19
Year Started: 2020
This study is part of a collaborative UK immunology network to understand how the immune system can protect against COVID-19 and develop relevant tests to help identify patients with better or worse outcomes following exposure to SARS-CoV-2. Our role is to investigate the part of the early warning system of the immune system: “the innate immune system”, and its response to COVID-19. We wish to study this part of the immune system in detail because other studies have overlooked this important part of the immune response to COVID-19. The cells of the innate immune system are present in a primed “ready-to-go” state in most individuals. However, it is possible that other infections, and even vaccines such as BCG, can give these cells a heightened state of readiness called “trained immunological memory”. We wish to test if individuals who have better outcomes from COVID-19, or are protected from infection have stronger innate immune systems with more cells in this “trained” state than those who have worse outcomes. Similarly, we wish to study if the innate immune system can determine which individuals will have more severe outcomes, such as respiratory failure. We will study this using assays of immune cell function and by phenotyping these cells at a molecular level. In this way, we will learn how the innate immune system responds to SARS-CoV-2 and investigate some of the molecular mechanisms involved. It is hoped that information from this work can inform useful immunological tests that will help to decide which patients are protected from infection and which patients may develop severe COVID-19 disease.
- Access:
- Access restricted at present
- Type:
- Cohort
- Status:
- In progress
- Consent restrictions:
-
Commercial restriction, Xenograft restriction
Associated Data Type |
Procurement Timeframe |
Biomarker datasets |
> 6 months |
Clinical records |
> 6 months |
Followup records |
> 6 months |
Freezer temperature logs |
> 6 months |
Pathology records |
> 6 months |
Physiological/biochemical measurements |
> 6 months |
Quality indicators |
> 6 months |
Donor Ethnicity |
> 6 months |
Female
Adult (> 40 years)
1 - 10 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
100% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
100% |
Serum |
|
-60°C to -85°C |
|
Not applicable |
100% |
Saliva |
|
-60°C to -85°C |
|
Not applicable |
100% |
Male
Adult (> 40 years)
1 - 10 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
100% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
100% |
Serum |
|
-60°C to -85°C |
|
Not applicable |
100% |
Saliva |
|
-60°C to -85°C |
|
Not applicable |
100% |
Female
Young adult (18 - 40 years)
1 - 10 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
100% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
100% |
Serum |
|
-60°C to -85°C |
|
Not applicable |
100% |
Saliva |
|
-60°C to -85°C |
|
Not applicable |
100% |
Male
Young adult (18 - 40 years)
1 - 10 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
100% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
100% |
Serum |
|
-60°C to -85°C |
|
Not applicable |
100% |
Saliva |
|
-60°C to -85°C |
|
Not applicable |
100% |
Malignant lymphoma (disorder)
PROSECO - A UK multicentre prospective observational study evaluating COVID-19 vaccine immune responses in lymphoid cancer
Year Started: 2021
Population-wide prophylactic vaccination is the principal means of quelling the COVID-19 pandemic. For this to succeed, knowledge of vaccine efficacy is imperative. Patients with lymphoid malignancies have an increased mortality risk from COVID-19. Many patients are apparently cured but have long-term immune defects. Our lack of knowledge of COVID-19 vaccination responses confers a morbidity and mortality risk in this population and significant societal impact.
This study will assess COVID-19 vaccine efficacy defined by immunological responses (anti-spike IgG, virus neutralisation, T-cell recall).
- Access:
- Access restricted at present
- Type:
- Disease specific
- Status:
- In progress
- Consent restrictions:
-
Commercial restriction, Xenograft restriction
Associated Data Type |
Procurement Timeframe |
Biomarker datasets |
> 6 months |
Clinical records |
> 6 months |
Followup records |
> 6 months |
Freezer temperature logs |
> 6 months |
Genomic datasets |
> 6 months |
Pathology records |
> 6 months |
Physiological/biochemical measurements |
> 6 months |
Quality indicators |
> 6 months |
Treatment records |
> 6 months |
Donor Ethnicity |
> 6 months |
Female
Young adult (18 - 40 years)
1 - 10 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
100% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
100% |
Male
Young adult (18 - 40 years)
1 - 10 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
100% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
100% |
Female
Adult (> 40 years)
1 - 10 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
100% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
100% |
Male
Adult (> 40 years)
1 - 10 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
100% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
100% |
Severe combined immunodeficiency due to absent interleukin-2 receptor (disorder)
Deep immuno-phenotyping to identify precision medicine targets in adult and paediatric patients with Combined Immunodeficiency
Year Started: 2016
Primary Immunodeficiencies (PIDs) are rare inherited diseases of the immune system that may lead to recurrent infections, malignancy or autoimmunity, all with a significantly impaired quality of life. There are currently over 200 different PIDs with approximately 250 different genes linked to these disorders. Through the NIHR/Wellcome Trust Southampton Clinical Research Facility for Experimental Medicine and Translational Medicine Laboratory, we will perform deep-phenotyping (detailed examination of possible pertinent findings of gene tests) of 20 patients with PID to gain additional understanding of the cause each patients’ rare immunological disease. This greater understanding will hopefully identify novel therapeutic targets and the initiation of personalised treatments. Previously at our centre we have shown that, by this approach, we can commence precision therapeutics for patients with PID that substantially reduced morbidity and mortality.
- Access:
- Access restricted at present
- Type:
- Disease specific
- Status:
- In progress
- Consent restrictions:
-
Commercial restriction, Xenograft restriction
Associated Data Type |
Procurement Timeframe |
Biomarker datasets |
> 6 months |
Clinical records |
> 6 months |
Followup records |
> 6 months |
Genomic datasets |
> 6 months |
Pathology records |
> 6 months |
Quality indicators |
> 6 months |
Treatment records |
> 6 months |
Donor Ethnicity |
> 6 months |
Male
Young adult (18 - 40 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
100% |
Serum |
|
-60°C to -85°C |
|
Not applicable |
100% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
100% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
100% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
51 - 75% |
Female
Adult (> 40 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
100% |
Serum |
|
-60°C to -85°C |
|
Not applicable |
100% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
100% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
100% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
51 - 75% |
Male
Adult (> 40 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
100% |
Serum |
|
-60°C to -85°C |
|
Not applicable |
100% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
100% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
100% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
51 - 75% |
Female
Young adult (18 - 40 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
100% |
Serum |
|
-60°C to -85°C |
|
Not applicable |
100% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
100% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
100% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
51 - 75% |
Female
Adolescent (12 - 18 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
100% |
Serum |
|
-60°C to -85°C |
|
Not applicable |
100% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
100% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
100% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
51 - 75% |
Male
Adolescent (12 - 18 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
100% |
Serum |
|
-60°C to -85°C |
|
Not applicable |
100% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
100% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
100% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
51 - 75% |
Female
Child (6 - 12 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
100% |
Serum |
|
-60°C to -85°C |
|
Not applicable |
100% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
100% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
100% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
51 - 75% |
Male
Child (6 - 12 years)
11 - 100 donors
Material Type |
Extraction Procedure |
Storage Temperature |
Preservation Type |
Macroscopic Assessment |
% of Sample Set |
Whole blood |
|
-60°C to -85°C |
|
Not applicable |
100% |
Serum |
|
-60°C to -85°C |
|
Not applicable |
100% |
Plasma |
|
-60°C to -85°C |
|
Not applicable |
100% |
RNA |
|
-60°C to -85°C |
|
Not applicable |
100% |
Peripheral blood mononuclear cells (PBMC) |
|
Liquid nitrogen vapor phase |
|
Not applicable |
51 - 75% |