Mesothelioma (malignant, clinical disorder) (disorder)

Mesobank

Year Started: 2014

REC approved, Research Tissue Bank providing fresh frozen samples of tumour, blood, pleural fluid and DNA.



Access:
Open to applicants
Type:
Disease specific
Status:
In progress
Consent restrictions:
Other animal work restriction, Xenograft restriction


Associated Data Type Procurement Timeframe
Clinical records Immediate
Freezer temperature logs Immediate
National registries Immediate
Pathology records Immediate
Physiological/biochemical measurements Immediate
Quality indicators Immediate
Treatment records Immediate
Donor Ethnicity Immediate


Female

Adult (> 40 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Pleural fluid PFL -60°C to -85°C Not applicable 51 - 75%


Male

Adult (> 40 years)

101 - 500 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Tissue specimen -60°C to -85°C Affected 75% -99%


Female

Adult (> 40 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Serum -60°C to -85°C Not applicable 75% -99%


Female

Adult (> 40 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
DNA -60°C to -85°C Not applicable 26 - 50%


Female

Adult (> 40 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Whole blood -60°C to -85°C Not applicable 51 - 75%


Female

Adult (> 40 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Buffy coat -60°C to -85°C Not applicable 51 - 75%


Male

Adult (> 40 years)

101 - 500 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Buffy coat -60°C to -85°C Not applicable 51 - 75%


Female

Adult (> 40 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Plasma -60°C to -85°C Not applicable 75% -99%


Male

Adult (> 40 years)

101 - 500 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Plasma -60°C to -85°C Not applicable 75% -99%


Male

Adult (> 40 years)

101 - 500 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Serum -60°C to -85°C Not applicable 75% -99%


Male

Adult (> 40 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
DNA -60°C to -85°C Not applicable 11 - 25%


Male

Adult (> 40 years)

101 - 500 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Pleural fluid PFL -60°C to -85°C Not applicable 51 - 75%


Female

Adult (> 40 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Tissue specimen -60°C to -85°C Affected 51 - 75%


Male

Adult (> 40 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Tissue specimen -60°C to -85°C Non-affected 51 - 75%


Female

Adult (> 40 years)

1 - 10 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Tissue specimen -60°C to -85°C Non-affected 100%


Male

Adult (> 40 years)

101 - 500 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Whole blood -60°C to -85°C Not applicable 51 - 75%

Mesothelioma (malignant, clinical disorder) (disorder)

TMA

Year Started: 2014

A tissue microarray (TMA) containing tumour cores from 800 patients is available. This has been constructed by the Cancer Research UK Cambridge TMA facility using paraffin-embedded blocks from cases that have been diagnosed in hospitals across the UK. A minimum of four cores is taken from each block to allow for tumour heterogeneity. The TMA has been constructed in modular form to facilitate test and validation cohorts. Cut slides are dipped in wax.



Access:
Open to applicants
Type:
Disease specific
Status:
Completed
Consent restrictions:
Other animal work restriction, Xenograft restriction


Associated Data Type Procurement Timeframe
Clinical records 0 - 3 months
Imaging data 0 - 3 months
National registries 0 - 3 months
Pathology records 0 - 3 months
Quality indicators 0 - 3 months
Treatment records 0 - 3 months
Donor Ethnicity 0 - 3 months


Female

Adult (> 40 years)

101 - 500 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Tissue specimen RT Affected 100%


Male

Adult (> 40 years)

501 - 1000 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Tissue specimen RT Affected 100%

Mesothelioma (malignant, clinical disorder) (disorder)

Cell Lines

Year Started: 2014

Mesobank currently has 21 primary cell lines available. These lines were originally derived by Professor Marion MacFarlane (MRC Toxicology Unit, University of Cambridge) and Dr Zsuzanna Tabi, (University of Cardiff). All lines are low passage and mycoplasma free. Each line has been characterised in terms of sub-type and growth characteristics.



Access:
Open to applicants
Type:
Disease specific
Status:
Completed
Consent restrictions:
No restrictions


Associated Data Type Procurement Timeframe
Genomic datasets Immediate
Quality indicators Immediate


Male

Adult (> 40 years)

11 - 100 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Cancer cell lines -60°C to -85°C Affected 100%


Female

Adult (> 40 years)

1 - 10 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Cancer cell lines -60°C to -85°C Affected 100%