Mesothelioma (malignant, clinical disorder) (disorder)
TMA
Year Started: 2014
A tissue microarray (TMA) containing tumour cores from 800 patients is available. This has been constructed by the Cancer Research UK Cambridge TMA facility using paraffin-embedded blocks from cases that have been diagnosed in hospitals across the UK. A minimum of four cores is taken from each block to allow for tumour heterogeneity. The TMA has been constructed in modular form to facilitate test and validation cohorts. Cut slides are dipped in wax.
- Access:
- Open to applicants
- Type:
- Disease specific
- Status:
- Completed
- Consent restrictions:
- Other animal work restriction, Xenograft restriction
| Associated Data Type | Procurement Timeframe |
|---|---|
| Clinical records | 0 - 3 months |
| Imaging data | 0 - 3 months |
| National registries | 0 - 3 months |
| Pathology records | 0 - 3 months |
| Quality indicators | 0 - 3 months |
| Treatment records | 0 - 3 months |
| Donor Ethnicity | 0 - 3 months |
Female
Adult (> 40 years)
101 - 500 donors
| Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
|---|---|---|---|---|---|
| Tissue specimen | RT | Affected | 100% |
Male
Adult (> 40 years)
501 - 1000 donors
| Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
|---|---|---|---|---|---|
| Tissue specimen | RT | Affected | 100% |
Mesothelioma (malignant, clinical disorder) (disorder)
Cell Lines
Year Started: 2014
Mesobank currently has 21 primary cell lines available. These lines were originally derived by Professor Marion MacFarlane (MRC Toxicology Unit, University of Cambridge) and Dr Zsuzanna Tabi, (University of Cardiff). All lines are low passage and mycoplasma free. Each line has been characterised in terms of sub-type and growth characteristics.
- Access:
- Open to applicants
- Type:
- Disease specific
- Status:
- Completed
- Consent restrictions:
- No restrictions
| Associated Data Type | Procurement Timeframe |
|---|---|
| Genomic datasets | Immediate |
| Quality indicators | Immediate |
Male
Adult (> 40 years)
11 - 100 donors
| Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
|---|---|---|---|---|---|
| Cancer cell lines | -60°C to -85°C | Affected | 100% |
Female
Adult (> 40 years)
1 - 10 donors
| Material Type | Extraction Procedure | Storage Temperature | Preservation Type | Macroscopic Assessment | % of Sample Set |
|---|---|---|---|---|---|
| Cancer cell lines | -60°C to -85°C | Affected | 100% |