Malignant tumor of kidney (disorder)

Renal Cancer Biomarkers (NIHR Biomarker Programme)

Year Started: 2011

706 patients recruited across 11 UK centres: 494 cross sectional cohort with single time point and 212 with multiple samples as a longitudinal cohort. 511 tissue samples: 375 FFPE only, 18 frozen only and 118 both. For each patient at each timepoint, multiple aliquots of EDTA plasma, serum, and urine are stored frozen at -80ºC together with a buffy coat sample. Digital images are available for some of the tissue samples. Clinical data including long-term follow-up is held by Leeds Clinical Trials Research Unit.



Access:
Open only through collaboration
Type:
Disease specific
Status:
Completed
Consent restrictions:
No restrictions


Associated Data Type Procurement Timeframe
Biomarker datasets 0 - 3 months
Clinical records 0 - 3 months
Followup records 0 - 3 months
Freezer temperature logs 0 - 3 months
Genomic datasets 0 - 3 months
Imaging data 0 - 3 months
Pathology records 0 - 3 months
Physiological/biochemical measurements 0 - 3 months
Treatment records 0 - 3 months


Unknown

Adult (> 40 years)

501 - 1000 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Plasma -60°C to -85°C N/A Not applicable 100%
Serum -60°C to -85°C N/A Not applicable 100%
Tissue specimen Surgical procedure (procedure) Liquid nitrogen liquid phase N/A Not applicable 11 - 25%
Tissue specimen Surgical procedure (procedure) RT Paraffin Not applicable 51 - 75%
Urine -60°C to -85°C N/A Not applicable 100%

Fit and well (finding)

Healthy controls in NIHR Biomarker Programme

Year Started: 2011

Cross-sectional EDTA plasma, serum and urine samples have been collected from 149 healthy controls across multiple UK centres together with relevant demographic data. Samples have been collected using standardised SOPs and aliquots are stored in multiple aliquots at -80ºC. Demographic data is held by Leeds Clinical Trials Research Unit



Access:
Open only through collaboration
Type:
Cross-sectional
Status:
Completed
Consent restrictions:
No restrictions


Associated Data Type Procurement Timeframe
Freezer temperature logs 0 - 3 months


Unknown

Adult (> 40 years)

101 - 500 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Plasma -60°C to -85°C N/A Not applicable 100%
Serum -60°C to -85°C N/A Not applicable 100%
Urine -60°C to -85°C N/A Not applicable 100%

Cirrhosis of liver (disorder)

ELUCIDATE Liver Cirrhosis Study

Year Started: 2011

847 patients with liver disease across multiple UK centres have consented and provided a single serum sample. Serum samples collected using standardised SOPs are stored in multiple aliquots at -80ºC. Clinical data is held by Leeds Clinical Trials Research Unit.



Access:
Open only through collaboration
Type:
Cross-sectional
Status:
Completed
Consent restrictions:
No restrictions


Associated Data Type Procurement Timeframe
Biomarker datasets 0 - 3 months
Clinical records 0 - 3 months
Followup records 0 - 3 months
Freezer temperature logs 0 - 3 months
Physiological/biochemical measurements 0 - 3 months
Treatment records 0 - 3 months


Unknown

Adult (> 40 years)

501 - 1000 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Serum -60°C to -85°C N/A Not applicable 100%