Hematologic neoplasm (disorder)

Causes of Clonal Blood Cell Disorders study

Year Started: 2007

Blood and related products, including viable cells and nucleic acids from patients with haematological disorders with clonal origins, such as leukaemia, myeloproliferative disorders, myelodysplasia, myeloma, lymphoma and related conditions. Samples collected at diagnosis or before commencing therapy where possible; and at progression of disease if available, in patients of all ages and gender. Samples collected as part of the REC-approved Causes of Clonal Blood Cell Disorders study.



Access:
Open to applicants
Type:
Disease specific
Status:
In progress
Consent restrictions:
No restrictions


Associated Data Type Procurement Timeframe
Biomarker datasets 0 - 3 months
Clinical records 0 - 3 months
Followup records 0 - 3 months
Freezer temperature logs 0 - 3 months
Genomic datasets 0 - 3 months
Pathology records 0 - 3 months
Quality indicators 0 - 3 months
Treatment records 0 - 3 months


Unknown

Data not recorded

3001 - 5000 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Peripheral blood mononuclear cells (PBMC) Liquid nitrogen liquid phase N/A Affected 75% -99%


Unknown

Data not recorded

3001 - 5000 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
DNA -60°C to -85°C N/A Affected 100%


Unknown

Data not recorded

3001 - 5000 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
RNA -60°C to -85°C N/A Affected 75% -99%


Unknown

Data not recorded

3001 - 5000 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Serum -60°C to -85°C N/A Affected 51 - 75%


Unknown

Data not recorded

3001 - 5000 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Plasma -60°C to -85°C N/A Affected 26 - 50%


Unknown

Data not recorded

501 - 1000 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Whole bone marrow Liquid nitrogen liquid phase N/A Affected 26 - 50%

Leukemia, disease (disorder)

UK MPN sample bank

Year Started: 2007

UK MPN sample bank contains samples from over 3000 patients with myeloproliferative neoplasms with associated clinical and research genomic data where available. The collection incorporates the PT1 trial sample cohort.



Access:
Open to applicants
Type:
Disease specific
Status:
In progress
Consent restrictions:
No restrictions


Associated Data Type Procurement Timeframe
Biomarker datasets 0 - 3 months
Clinical records 0 - 3 months
Followup records 0 - 3 months
Genomic datasets 0 - 3 months
Treatment records 0 - 3 months


Unknown

Data not recorded

3001 - 5000 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Peripheral blood mononuclear cells (PBMC) Liquid nitrogen liquid phase N/A Affected 51 - 75%


Unknown

Data not recorded

3001 - 5000 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
DNA -60°C to -85°C N/A Affected 75% -99%


Unknown

Data not recorded

3001 - 5000 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Serum -60°C to -85°C N/A Affected 75% -99%


Unknown

Data not recorded

3001 - 5000 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
RNA -60°C to -85°C N/A Affected 75% -99%

Fit and well (finding)

Cord blood collection (sub-collection containing normal samples for the Causes of Clonal Blood Cell Disorders study)

Year Started: 2011

Viable cord blood cells, either as mononuclear cells, CD34 positive or CD34 negative cells.



Access:
Open to applicants
Type:
Cohort
Status:
In progress
Consent restrictions:
No restrictions


Associated Data Type Procurement Timeframe
Freezer temperature logs 0 - 3 months
Warm ischemic time 0 - 3 months


Unknown

Neonate (0 - 1 month)

101 - 500 donors

Material Type Extraction Procedure Storage Temperature Preservation Type Macroscopic Assessment % of Sample Set
Peripheral blood mononuclear cells (PBMC) Liquid nitrogen liquid phase N/A Non-affected 100%