A Phase II non-randomised multicentre trial of docetaxel, cisplatin & 5-fluorouracil chemotherapy (TPF) in locally advanced and metastatic carcinoma of the penis. 26 evaluable patients recruited to receive Docetaxel 75mg/m2 day 1, cisplatin 60mg/m2 day 1, 5-fluorouracil 750mg/m2/day (day 1-5), peated at intervals of 21 days. The primary endpoint, measured by RECIST v1, (complete remission rate + partial remission rate). Secondary endpoints are te proportion of patients with inoperable locoregional disease rendered operable by TPF chemotherapy, progression-free survival, overall survival, acute toxicity (as determined by CTCAE) after each cycle and at 3 months and late toxicity (CTCAE). Formalin fixed paraffin embedded tissue samples are held at the Orchid Research Tissue Bank at Barts and the London School of Medicine and Dentistry.
- Malignant tumor of penis (disorder)
Orchid Research Tissue Bank
John Vane Science Centre
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