Avon Longitudinal Study of Parents and Children (ALSPAC)
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The Avon Longitudinal Study of Parents and Children (ALSPAC) is a longitudinal cohort study which has been charting the health of 14,500 families in the Bristol area since the early 1990s in order to improve the health of future generations. The study is also known as the Children of the 90s study. Mothers were recruited during pregnancy. The children born in 1991 and 1992 (known as ALSPAC-G1) and their mothers and fathers (G0) have been followed since. A large amount of phenotypic and environmental exposure data has been collected via questionnaires, research clinics and record linkage. The study website contains details of all the data that is available through a searchable data dictionary. Many of the original participants are now becoming parents and we are recruiting the next generation of children (ALSPAC-G2). Therefore ALSPAC is able to make a completely unique contribution to health science, by being able to understand how health, well-being and disease are passed through families. Samples have been collected throughout the participants lives and include DNA, lymphoblastoid cell lines, blood, urine, saliva, placentas, hair, nails and milk teeth. A large amount of omics data has been generated from samples including genetic, epigenetic and metabolomic data. The samples and data form a resource for the scientific community for projects which comply with our access conditions as outlined in our access policy. This can be found on our study website. All data generated from samples must be returned to ALSPAC for inclusion in the data resource and will be made available to other researchers. Study participants can be recalled for specific sample and/or data collection exercises eg for recall by genotype, phenotype or exposure studies. Such studies will be designed on a case by case basis and will be subject to appropriate ethical approval. Please contact the laboratory (email addresses in contact section) to discuss sample requirements. Publications can be found at https://www.bristol.ac.uk/alspac/researchers/publications/

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Last Updated: 05/04/2023

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